Takeaways
- Omega-3 fatty acids are essential fats our bodies can’t produce
- ALA, EPA, and DHA are the main types of omega-3s
- Omega-3s support heart, brain, and eye health
- Both plant and animal sources provide omega-3s
- Balancing omega-3 and omega-6 intake is important for health
What Are Omega-3 Fatty Acids?
Omega-3 fatty acids are a type of fat that the human body cannot produce on its own, meaning they must be obtained through diet or supplements.[1] These fats are crucial for many essential bodily functions.
There are three primary kinds of omega-3s: ALA, EPA, and DHA.[2] Each one plays a distinct role in maintaining overall health. Understanding their differences is key to appreciating the importance of omega-3s.
Omega-3s are classified as polyunsaturated fats, characterized by multiple double bonds within their chemical structure.[3] This unique arrangement contributes to the various health benefits associated with these fats.
The common names and their abbreviations for each type of omega-3 are listed below:
- ALA: Alpha-linolenic acid
- EPA: Eicosapentaenoic acid
- DHA: Docosahexaenoic acid
The Omega-3 Family: ALA, EPA, and DHA
Alpha-Linolenic Acid (ALA)
ALA, or alpha-linolenic acid, is a plant-based omega-3, found in foods like seeds, nuts, and certain oils.[4] The body can use ALA directly or convert it to other omega-3s.
The body has the ability to convert ALA into EPA and DHA, however, this process is not very efficient.[5] Only a small percentage of ALA is actually transformed into EPA and DHA.
While many people consume enough ALA through their diet, its conversion to EPA and DHA is limited.[6] This is why getting EPA and DHA directly from sources like food or supplements is often recommended.
Eicosapentaenoic Acid (EPA)
EPA, or eicosapentaenoic acid, is mainly sourced from marine life, like fish and algae.[7] It is known for helping to reduce inflammation throughout the body.[8]
EPA plays a role in supporting heart health by helping to lower triglyceride levels.[9] It may also have a positive impact on mood and mental health, with some studies suggesting it can help with symptoms of depression.[10]
Docosahexaenoic Acid (DHA)
DHA, or docosahexaenoic acid, is particularly important for brain and eye health.[11] Like EPA, it is mainly found in marine sources. DHA is a vital component of brain cell membranes.
DHA is crucial during pregnancy and early childhood because it supports the development of the brain and eyes in babies.[12] Adults also require DHA to maintain healthy brain function as they age.[13]
Omega-3 Type | Main Sources | Primary Functions | Conversion Rate |
---|---|---|---|
ALA | Plant oils, seeds, nuts | Converted to EPA and DHA | Low (5-15%) |
EPA | Fish, algae | Reduces inflammation, supports heart health | N/A |
DHA | Fish, algae | Brain and eye health | N/A |
Omega-3 Food Sources
Plant-Based Sources
Plants are a source of ALA, the simplest form of omega-3.[14] The body can use ALA or convert it to other omega-3s. Many common foods contain ALA, making it easily accessible.
Here are some of the top plant-based sources of omega-3s:
- Flaxseeds and flaxseed oil
- Chia seeds
- Walnuts
- Hemp seeds
- Soybeans and soybean oil
- Canola oil
Plant-based omega-3s are readily available in many foods and easy to incorporate into your diet.[15] However, the body doesn’t absorb them as well as omega-3s from animal sources, so larger quantities may be needed to obtain similar benefits.[16]
Animal-Based Sources
Fish and seafood are excellent sources of EPA and DHA, which are more easily used by the body.[17] Unlike ALA, these do not require conversion, making them readily available for use by the body.
Some fish that are high in omega-3s include:
- Salmon
- Mackerel
- Sardines
- Anchovies
- Herring
- Tuna
Cold-water fish tend to have higher concentrations of omega-3s.[18] They rely on these fats to maintain flexibility in colder temperatures, making them a great source for human consumption.
Fortified Foods
Some foods are enriched with added omega-3s to boost nutritional content. These fortified foods can be a convenient way to increase your intake. Examples include:
- Eggs from chickens fed omega-3-rich diets
- Milk and yogurt with added DHA
- Bread and pasta enriched with omega-3s
- Some brands of orange juice
Fortified foods can offer convenience, but generally contain lower amounts of omega-3s compared to natural sources.[19] They should be used to supplement, not replace, other omega-3 sources.
Health Benefits of Omega-3s
Heart Health
Omega-3s benefit heart health in multiple ways. They can help lower triglyceride levels and reduce blood pressure, which supports overall heart function.[20]
These fats also help prevent plaque buildup in arteries, which can lead to serious health issues such as heart attacks and strokes.[21] Omega-3s’ anti-inflammatory properties also help to protect blood vessels.
Omega-3s contribute to heart health by:
- Lowering triglycerides
- Reducing blood pressure
- Decreasing plaque in arteries
- Fighting inflammation
- Improving blood vessel function
Regular consumption of omega-3s is linked to a reduced risk of heart disease.[22] For this reason, the American Heart Association recommends eating fish twice a week.[23]
Brain Function
Omega-3s are very important for brain health. DHA, in particular, is a major component of brain tissue, helping brain cells communicate and protecting them from damage.[24]
These fats may also improve memory and thinking skills.[25] Some studies suggest that omega-3s can slow cognitive decline in older adults and potentially reduce the risk of Alzheimer’s disease.[26]
Omega-3s also affect mood and mental well-being. Specifically, EPA may help with symptoms of depression and anxiety by reducing brain inflammation, a factor that can contribute to these conditions.[27]
Inflammation Reduction
Omega-3s are natural anti-inflammatory agents, helping to balance the body’s inflammation response.[28] This can have a positive impact on many aspects of overall health.
Chronic inflammation is linked to many health problems, such as heart disease, cancer, and arthritis.[29] By reducing inflammation, omega-3s may contribute to lowering the risk of these diseases.
Individuals with inflammatory conditions often experience benefits from omega-3s.[30] They may ease joint pain associated with rheumatoid arthritis, and can also be helpful with inflammatory bowel diseases.
Eye Health
DHA is found in high concentrations within the retina of the eye. It helps maintain good vision and overall eye health.[31] Omega-3s may also offer protection against age-related eye problems.
Research indicates that omega-3s can be helpful for individuals with dry eye syndrome, increasing tear production and reducing inflammation, which can improve overall comfort.[32]
Omega-3s may also play a role in preventing macular degeneration, a leading cause of vision loss in older adults.[33] Regular consumption of fish is linked to a lower risk of developing this condition.
Omega-3 Supplements
Fish Oil
Fish oil is a common source of EPA and DHA, extracted from the tissues of oily fish.[34] It is available in various forms, such as capsules, liquids, or gummies.
The concentration of EPA and DHA can vary between different fish oil products. It’s important to always read the label to ensure you are getting the intended amount.[35]
Fish oil can sometimes leave a fishy taste or cause burping.[36] Taking fish oil with meals or even freezing the capsules can often help to reduce these side effects.
Algae-Based Supplements
Algae supplements provide a vegan source of EPA and DHA, derived from marine algae, where fish obtain their omega-3s.[37]
These supplements are an excellent option for vegetarians, vegans, and people with fish allergies. Algae oils often have higher concentrations of omega-3s compared to fish oil.
Algae supplements primarily provide DHA; however, some newer products also include EPA, making it a more complete, sustainable alternative to fish oil.
Krill Oil
Krill oil is derived from tiny crustaceans called krill. Similar to fish oil, it contains both EPA and DHA but also has other unique characteristics.
The omega-3s found in krill oil are bound to phospholipids, which may improve their absorption by the body. Additionally, krill oil contains astaxanthin, an antioxidant.
Some people find krill oil easier to digest than fish oil, with less fishy burping. However, krill oil tends to be more expensive and typically contains less EPA and DHA per serving compared to fish oil.
Supplement Type | Source | Omega-3 Content | Potential Benefits |
---|---|---|---|
Fish Oil | Oily fish | High EPA and DHA | Heart and brain health |
Algae Oil | Marine algae | Mainly DHA, some EPA | Vegan-friendly, sustainable |
Krill Oil | Krill | EPA and DHA with phospholipids | Possibly better absorption |
Omega-3 Intake Recommendations
The amount of omega-3s needed varies based on individual factors, including age, overall health, and diet. There is no single recommended amount that applies to everyone.
The American Heart Association suggests eating fish twice a week, which provides roughly 250-500 mg of combined EPA and DHA daily. People with heart disease may need to consume around 1 gram per day.
To ensure you are getting enough omega-3s:
- Eat fatty fish twice a week
- Include plant sources of ALA in your diet
- Consider a supplement if you don’t eat fish
- Talk to your doctor about your specific needs
- Check food labels for omega-3 content
It’s important to remember that more is not always better, as very high doses can lead to side effects. Always consult a doctor or healthcare provider before beginning any new supplement regimen.
Balancing Omega-3 and Omega-6
Omega-3 and omega-6 are both essential fatty acids, and maintaining a balance between the two is important. Most Western diets tend to be too high in omega-6 and too low in omega-3.
A typical Western diet has an omega-6 to omega-3 ratio of about 16:1, while experts suggest a healthier ratio is closer to 4:1 or even 1:1. Too much omega-6 can promote inflammation.
To help improve your omega-3 to omega-6 balance:
- Eat more fatty fish
- Use oils high in omega-3s, like flaxseed oil
- Limit processed foods high in omega-6s
- Choose grass-fed meat over grain-fed
- Snack on walnuts instead of other nuts
Achieving a healthy balance between these fats can help reduce overall inflammation, which may lower the risk of developing chronic diseases.
Potential Risks and Side Effects
While omega-3s are generally considered safe, high doses may cause some problems. Common side effects can include:
- Fishy taste or breath
- Digestive discomfort
- Nausea
- Loose stools
Omega-3s can interact with some medications. They may increase the risk of bleeding when taken with blood thinners. It’s important to inform your doctor about any supplements you are using.
Very high doses of omega-3s could suppress immune function or increase LDL cholesterol (bad) levels in some individuals. Stick to recommended doses unless otherwise directed by a doctor.
You should seek advice from a healthcare provider if:
- Before starting high-dose supplements
- If you’re on blood thinners or other medications
- If you have a fish or shellfish allergy
- If you experience unusual side effects
The quality of omega-3 supplements is important. Choose brands that have been tested for purity and potency to minimize contamination from substances like mercury.
Omega-3s for Special Populations
Pregnancy and Breastfeeding
Omega-3s are very important during pregnancy and breastfeeding, supporting the development of the fetus’s brain and eyes. DHA is particularly crucial in the last trimester of pregnancy.
Pregnant women should aim to consume 200-300 mg of DHA per day through diet or supplements. Eating low-mercury fish is a good way to get omega-3s.
Breastfeeding mothers also need omega-3s to help ensure their baby receives adequate amounts. The amount of DHA in breast milk is dependent on the mother’s intake of omega-3s.
Children and Adolescents
Children require omega-3s for proper growth and development. These fats support brain function, vision, and the immune system. The specific amount needed varies based on age.
For children, obtaining omega-3s through foods is best. Fatty fish, walnuts, and fortified foods are all options. Consult a doctor before giving a child omega-3 supplements, especially if they don’t eat fish.
Some research indicates that omega-3s may help reduce ADHD symptoms in children, although more studies are needed. Always seek a doctor’s advice before giving children any kind of supplement.
Older Adults
Omega-3s continue to be important as we age, helping to maintain cognitive function and eye health. They can also help to reduce inflammation associated with aging.
Older adults should aim to consume fatty fish regularly. If this isn’t possible, supplements can help; however, consulting with a doctor, particularly if taking medications, is advised.
Some research suggests omega-3s could help prevent age-related macular degeneration and cognitive decline; however, the results are varied and more studies are needed.
Omega-3 Testing
A blood test can measure your omega-3 levels by determining the amount in your red blood cells. This test is called the Omega-3 Index.
An Omega-3 Index of 8% or higher is considered optimal, while a level below 4% is associated with higher health risks. This test can help guide your omega-3 intake.
Testing might be recommended if:
- You have heart disease risk factors
- You’re considering high-dose supplements
- You want to track the effects of dietary changes
- You have inflammation-related conditions
Remember that testing is not necessary for everyone. Many people can achieve healthy omega-3 levels by making dietary changes.
Cooking with Omega-3 Rich Foods
Adding foods rich in omega-3s to your diet can be easy and enjoyable. Here are some helpful tips:
- Grill or bake salmon for a quick, omega-3 packed meal
- Add ground flaxseed to smoothies or oatmeal
- Use walnut oil in salad dressings
- Snack on chia seed pudding
- Try sardines on whole-grain toast
When using oils rich in omega-3s, use low heat during cooking because high temperatures can damage these delicate fats. Consider adding flaxseed oil to food after it’s been cooked to keep its benefits.
Canned fish is a convenient and affordable source of omega-3s. Choose varieties packed in water instead of oil to keep the natural omega-3 content intact.
Although fresh fish is ideal, frozen fish can be just as nutritious because it is often frozen quickly after being caught, which helps to preserve its omega-3 content.
FAQ
How much omega-3 should I take daily?
Can you take too much omega-3?
What are the signs of omega-3 deficiency?
Is fish oil the same as omega-3?
Do omega-3 supplements really work?
Which is better: fish oil or krill oil?
Can vegetarians get enough omega-3?
How long does it take for omega-3 to work?
The human body lacks the enzymes necessary to synthesize omega-3 fatty acids, making them essential nutrients that must be consumed.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
These are the most commonly discussed and researched omega-3 fatty acids, each with unique roles and sources.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
The presence of multiple double bonds is a key structural feature of polyunsaturated fats, including omega-3s, and contributes to their properties.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
ALA is the primary omega-3 fatty acid derived from plant sources and is a precursor to EPA and DHA.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
The conversion process is limited by enzyme activity and other factors, resulting in a small percentage of ALA being converted into EPA and DHA.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
Because of the limited conversion rate, direct sources of EPA and DHA are often recommended for optimal intake.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
Fish and algae are rich sources of EPA, which they obtain from consuming smaller organisms like algae.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
EPA has been shown to have anti-inflammatory effects that can benefit various health conditions.
Source: “A combination of LCPUFA ameliorates airway inflammation in asthmatic mice by promoting pro-resolving effects and reducing adverse effects of EPA” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181394/
Studies have demonstrated that EPA can reduce triglyceride levels, a risk factor for heart disease.
Source: “Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791266/
While research is ongoing, some studies have indicated that EPA may help with depressive symptoms. More research is still needed to determine the extent of the benefits and the mechanisms involved.
Source: “Omega-3 Polyunsaturated Fatty Acids in Depression” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354246/
DHA is a major structural component of brain cell membranes and the retina, making it essential for their proper function.
Source: “Investigation of Lysophospholipids-DHA transport across an in vitro human model of blood brain barrier” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483317/
Adequate DHA intake during pregnancy is crucial for the optimal development of the brain and visual system of the fetus. DHA is also important for infants and young children as their brain continues to grow.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
DHA continues to play an essential role in maintaining brain health and cognitive function throughout adulthood.
Source: “Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139751/
ALA is a precursor to other omega-3s, but the body must convert it.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
Foods like flaxseeds, chia seeds, and walnuts are excellent sources of ALA.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
Due to limited conversion of ALA to EPA and DHA, higher intakes are required to achieve the same benefits as direct sources of EPA and DHA. Bioavailability is also an issue, as absorption of ALA varies.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
EPA and DHA from fish and seafood are more readily available for the body to use because they do not need to be converted.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
Cold-water fish species such as salmon, mackerel, and tuna tend to accumulate higher levels of omega-3s.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
While fortified foods can be a convenient source, they usually don’t contain as high levels of omega-3s as whole foods or supplements.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
Omega-3s have been shown to have cardiovascular benefits, including lowering triglyceride levels and blood pressure which support proper heart function.
Source: “Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791266/
While some research suggests that omega-3s may help prevent plaque buildup, which is a major contributor to heart attacks and strokes, more studies are needed to fully understand the mechanism and extent of this benefit. Other lifestyle and dietary habits play a larger role in preventing arterial plaque buildup.
Source: “Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791266/
Multiple studies have demonstrated an association between regular omega-3 consumption and a lower risk of heart disease.
Source: “Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts’ Committee Of National Society Of Cardiometabolic Medicine” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791266/
This recommendation is based on the benefits of consuming omega-3s from fish and their positive effects on cardiovascular health. Note that AHA also encourages other methods of obtaining proper amounts of omega-3 fatty acids.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
DHA is a major structural component of brain cell membranes, which are critical for optimal function and protection.
Source: “Omega-3 Polyunsaturated Fatty Acids in Depression” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354246/
Research suggests that omega-3s can positively influence cognitive function and memory, however, further studies are needed to fully explore the extent of these benefits. The impact of Omega-3s on cognition is not consistent across all studies, and is a topic of ongoing research.
Source: “Omega-3 Polyunsaturated Fatty Acids in Depression” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354246/
Some studies suggest omega-3s may have a role in slowing cognitive decline and reducing the risk of neurodegenerative diseases like Alzheimers, but more studies are needed to fully understand these effects.
Source: “The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447496/
EPA’s anti-inflammatory properties have been shown to help reduce brain inflammation, which can contribute to depression and anxiety. However, more research is needed to fully understand these effects.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
Omega-3s help balance the body’s inflammation response and this can have various positive effects on overall health.
Source: “A combination of LCPUFA ameliorates airway inflammation in asthmatic mice by promoting pro-resolving effects and reducing adverse effects of EPA” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181394/
Chronic inflammation is a risk factor for many health problems, including heart disease, cancer and arthritis. By reducing chronic inflammation, omega 3s may help lower the risk of these diseases.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
While omega-3s can help manage some inflammatory conditions, the extent of benefits varies between individuals and conditions.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
DHA is essential for proper visual function because it is a major component of the retinal tissue.
Source: “Dietary DHA amplifies LXA4 circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279588/
Some research suggests that omega-3 supplementation can help increase tear production and reduce inflammation associated with dry eye syndrome, thus potentially improving overall comfort. Results have been inconsistent across various studies.
Source: “Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917524/
Some studies suggest that omega-3s may help prevent macular degeneration, but more studies are needed to fully understand this role.
Source: “Omega-3 Fatty Acids and Eye Health: Opinions and Self-Reported Practice Behaviors of Optometrists in Australia and New Zealand” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230711/
Fish oil is extracted from tissues of oily fish and is a common source of EPA and DHA.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
The levels of EPA and DHA can differ depending on the type of fish and manufacturing process. Always check product labels to verify the amounts of each omega-3.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/
Fish oil supplements can cause a fishy aftertaste or burping in some individuals. This is a common and harmless side effect.
Algae oil is a plant-based source of omega-3s, particularly EPA and DHA, and is where fish obtain these fats through their diet.
Source: “Biotechnological production of omega-3 fatty acids: current status and future perspectives” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662050/