Table of Contents

Guggul Side Effects: How to Take It Safely

Takeaways

  • Guggul may cause digestive issues in some people
  • Skin reactions can occur when using guggul supplements
  • Guggul might interact with certain medications
  • Pregnant women should avoid taking guggul
  • Proper dosage and quality control are essential for safe use

Understanding Guggul

Guggul is a substance derived from the resin of the Commiphora mukul tree, which is native to India and its surrounding regions.[1] This resin has been used in traditional Ayurvedic medicine for many centuries.[2] Currently, guggul is widely recognized and used in wellness practices around the world.

Historically, guggul was used by traditional healers to address a range of health issues including arthritis, skin problems, and for weight management.[3] Contemporary research is now focused on understanding how guggul impacts cholesterol levels and inflammation in the body.[4]

Guggul supplements are available in several forms, such as capsules, tablets, and liquid extracts. Additionally, some individuals use guggul in topical creams. The increasing interest in natural health solutions has contributed to the growing popularity of guggul.


What is Guggul?

Botanical Profile

The guggul tree is a small, thorny species that thrives in dry areas of India, producing a yellowish resin.[5] This resin contains the active compounds that are utilized for medicinal purposes. The harvesting process requires careful and precise tapping of the tree’s bark to collect the resin.

The harvested resin undergoes an extraction and purification process to create supplements.[6] This processing method ensures that the beneficial compounds found in guggul are preserved. The final result is a concentrated version of the natural elements found in the tree.

Historical Uses

Guggul is mentioned in Ayurvedic texts dating back 2000 years.[7] Ancient healers highly valued it as a treatment for various health conditions. They utilized guggul to treat issues such as joint discomfort, skin ailments, and obesity.

Guggul was considered a very important substance in India and neighboring countries, recognized for its versatile medicinal applications. People used it both internally and externally to address a wide range of health problems.

Traditional uses of guggul include:

  • Treating arthritis and inflammation
  • Aiding weight loss
  • Improving skin health
  • Supporting heart health
  • Balancing thyroid function

Active Compounds in Guggul

Guggul contains several active substances that contribute to its medicinal properties. Among these compounds, guggulsterones are the most extensively studied.[8]

Compound Potential Effects
Z-guggulsterone May lower cholesterol
E-guggulsterone Could have anti-inflammatory properties
Guggulipid Might support thyroid function
Flavonoids May act as antioxidants

The different compounds within guggul work together to create the effects that have been observed throughout traditional and current use. Scientists are studying these substances to gain a better understanding of guggul’s benefits.

The complex mixture of compounds within guggul gives it unique properties. Each individual component may have a different effect. This complexity may explain why guggul has a wide range of traditional uses.


Potential Benefits of Guggul

People use guggul for several potential health benefits. Research has explored many of these, however, while studies show some promise, further investigation is still needed.

Scientists have conducted studies to examine the effects of guggul on cholesterol management and weight loss.[9] Results have been mixed, but certain findings support some of the traditional uses of guggul.

Cholesterol Management

Guggul may have an effect on cholesterol levels within the body. Some research suggests it could lower total cholesterol and also reduce levels of LDL cholesterol, which is often referred to as ‘bad’ cholesterol.[10]

A review of multiple studies on guggul showed varied outcomes. Some studies found that guggul was effective in managing cholesterol, while others didn’t see any notable changes. The differences may be due to varying quality in the guggul extracts that were used.

Weight Management

Guggul supplements are frequently used by people trying to lose weight, based on its traditional uses in Ayurvedic medicine. This claim has been the subject of modern research.

Some studies suggest that guggul might influence metabolism, which could potentially aid in weight management.[11] However, results from research studies have not been consistent across all trials.

Other Potential Benefits

Researchers have explored other potential effects of guggul, and while more research is needed, initial results are showing some interesting possibilities.

Other areas where guggul shows potential include:

  • Reducing inflammation
  • Supporting thyroid function
  • Improving skin health
  • Managing arthritis symptoms

Common Side Effects of Guggul

Similar to other supplements, guggul may cause side effects. It is important to be aware of these effects to use guggul safely. The majority of side effects are not serious, but some people may experience stronger reactions.

Side effects can differ from person to person, and one person’s reaction might not be the same for another. It is important to pay attention to your body’s response while using guggul.

Gastrointestinal Issues

Digestive issues are a common side effect of guggul use. Some individuals experience stomach discomfort after taking it.[12] While generally not severe, these problems can be uncomfortable.

Common digestive side effects include:

These effects often lessen as your body gets used to the guggul. Taking guggul with food might help reduce these problems. If the issues continue, you may need to reduce your dose or discontinue use.

Skin Reactions

Some people develop skin reactions when using guggul. These can vary from mild rashes to more serious allergic reactions.[13] Skin problems can occur whether guggul is taken orally or used topically.

Possible skin reactions include:

  • Rashes
  • Itching
  • Redness
  • Hives

If you notice any skin changes, stop using guggul immediately. See a doctor if symptoms worsen or do not get better. Those with sensitive skin should be particularly careful when using guggul.

Headaches and Dizziness

Headaches and dizziness can sometimes occur with guggul use.[14] These side effects are usually not severe and temporary, but can still be bothersome to some people.

If you experience persistent headaches or dizziness, you should stop using guggul. These symptoms may signal an adverse reaction. If the issues persist after discontinuing use, you should consult a healthcare professional.


Less Common but Serious Side Effects

Though not common, some people could experience more serious side effects from guggul. These require prompt medical attention. Understanding these possibilities can help users stay safe.

Serious side effects are rare but can be dangerous. If you notice unusual symptoms, seek medical help right away. Prompt action can help prevent further complications.

Allergic Reactions

Severe allergic reactions to guggul are rare, but can happen. If not treated quickly, these reactions could be life-threatening. Those with known allergies to other plants should use guggul with caution.

Signs of a serious allergic reaction include:

  • Difficulty breathing
  • Swelling of the face, lips, tongue, or throat
  • Severe dizziness
  • Rapid heartbeat

If you experience these symptoms, seek emergency medical help immediately. Do not wait to see if the symptoms improve without medical assistance.

Liver Function Changes

Some studies suggest that guggul might affect liver function.[15] Though not a common occurrence, this requires attention. Individuals with pre-existing liver problems should be especially cautious when using guggul.

Signs of liver issues include:

  • Yellowing of the skin or eyes
  • Dark urine
  • Abdominal pain
  • Unusual fatigue

Regular liver function tests can be helpful for monitoring any potential problems. If you have concerns, speak to your doctor before you begin using guggul.


Who Should Avoid Guggul?

Certain individuals should avoid guggul because their health conditions or medications could interact negatively with it. It’s crucial to determine if you fall into one of these categories.

Condition/Medication Reason to Avoid
Pregnancy Potential risks to fetus
Breastfeeding Unknown effects on infants
Blood disorders May increase bleeding risk
Thyroid conditions Could affect thyroid function
Liver disease Possible liver stress

It is recommended that you always consult with a healthcare provider before starting to use guggul. They can help you decide whether it is safe for you to use based on your individual health needs.

Pregnancy and Breastfeeding

Pregnant women should not use guggul supplements.[16] The potential effects on fetal development have not been studied. It is better to be cautious during pregnancy and avoid guggul.

Breastfeeding mothers should also avoid guggul.[17] It is not known how guggul might affect nursing infants. It is best to wait until after breastfeeding before considering using guggul.

Pre-existing Medical Conditions

People with specific health conditions should be cautious when using guggul. It could potentially worsen their health conditions, or interfere with other treatments they may be taking.

Medical conditions that warrant caution include:

  • Thyroid disorders
  • Liver disease
  • Bleeding disorders
  • Autoimmune diseases

If you have any chronic health issues, it is important to consult with your doctor first. They can advise you on whether guggul is safe for you.


Drug Interactions

Guggul can interact with various types of medications. These interactions could change how your medications work, and some combinations may be unsafe.

It is essential to understand possible drug interactions to help avoid any unexpected side effects or reduced effectiveness of other medications you might be taking.

Blood Thinners

Guggul could potentially enhance the effects of blood-thinning drugs.[18] This combination may increase the risk of bleeding. People who take anticoagulants should avoid using guggul.

Common blood thinners that may interact with guggul include:

  • Warfarin
  • Heparin
  • Aspirin (in high doses)

If you are taking blood thinners, you should consult your doctor before using guggul. They might need to adjust the dose of your medications.

Thyroid Medications

Guggul may have an effect on thyroid hormone levels, which could interfere with thyroid medications.[19] People who have thyroid conditions should be particularly cautious when taking guggul.

Thyroid medications that may interact with guggul include:

  • Levothyroxine
  • Liothyronine
  • Thyroid hormone replacements

If you are taking both guggul and thyroid medication, you should have regular thyroid function tests. Your doctor may need to adjust your medication dose based on your test results.


How to Take Guggul Safely

Using guggul safely involves following some guidelines. Proper dosage and timing can help to maximize benefits and minimize risks. Always begin with the lowest possible dose.

Safe guggul usage includes choosing quality products and paying attention to how your body reacts, in addition to taking the correct amount.

Dosage Recommendations

Guggul dosages vary based on the specific supplement product and the intended health use. Most studies have used between 25 and 125 mg of guggulsterones daily, which generally corresponds to 1000 to 2000 mg of guggul extract.[20]

Factors that influence guggul dosage include:

  • Your health condition
  • Body weight
  • Age
  • Other medications you’re taking

Start with a low dose and then increase it gradually as needed. This approach helps you to find the most effective amount for your individual needs.

Steps to determine the right guggul dosage:

  1. Consult a healthcare provider
  2. Start with the lowest recommended dose
  3. Monitor for effects and side effects
  4. Adjust dosage slowly if needed
  5. Don’t exceed the maximum recommended dose

Form and Timing

Guggul supplements are available in various forms. Capsules and tablets are the most commonly used forms. Some people also use liquid extracts or topical products.

The best time to take guggul can depend on its form and your daily schedule. It is often recommended to take it with meals, which can reduce stomach discomfort. It can also be helpful to split the daily dose into two or three servings throughout the day.

Consider these factors when choosing a guggul form:

  • Ease of use
  • Absorption rate
  • Potential for stomach irritation
  • Your personal preference

Consistency is essential when using guggul, so try to take it at the same times every day. This practice will help maintain consistent levels in your body.


Monitoring Your Body’s Response

It’s very important to monitor how guggul affects you. Each individual will react differently to supplements. By monitoring, you can identify any benefits and any potential side effects.

Keep a record of any changes that you notice after starting to use guggul. This information can help you and your healthcare provider make informed decisions about your treatment.

Keeping a Supplement Journal

A supplement journal can be very useful. It helps you to track your use of guggul and any effects it has on your body. This kind of record can reveal any patterns that might develop over time.

Benefits of keeping a supplement journal:

  • Helps identify positive changes
  • Allows early detection of side effects
  • Provides useful info for your doctor
  • Helps determine optimal dosage

Steps to create and maintain a supplement journal:

  1. Choose a format (notebook or digital app)
  2. Record daily dosage and timing
  3. Note any changes in symptoms or health
  4. Track energy levels and mood
  5. Write down any side effects, even minor ones

Regularly review your journal. Look for any trends or changes that may be connected to your use of guggul. Share this information with your healthcare provider at your check-ups.


When to Consult a Healthcare Professional

It is very important to discuss your guggul use with a healthcare provider. They can offer tailored advice based on your health history. In certain situations, immediate medical attention is required.

Do not hesitate to seek medical attention if you have any concerns. It is better to be cautious when it comes to your health.

Signs that require professional evaluation:

  • Severe allergic reactions
  • Persistent digestive problems
  • Unusual bleeding or bruising
  • Significant changes in mood or energy
  • Worsening of existing health conditions

Always inform your doctor about your guggul use. This information can help them to provide better care and to avoid any potential drug interactions.


Purchasing Quality Guggul Supplements

Choosing guggul supplements that are high-quality is vital for both safety and effectiveness. Not all products on the market are of the same quality. Knowing what to look for can help you make good choices.

Quality control practices vary across different supplement manufacturers. Some companies are more reliable than others. It is helpful to research various brands before you make a purchase.

Third-Party Testing

Third-party testing adds an additional level of quality assurance. Independent labs evaluate supplements for purity and strength. This testing helps to ensure that the product is what the label says it is.

Look for products that have certifications from trustworthy testing organizations, such as NSF International or USP. These types of certifications indicate that the products meet higher quality standards.

Benefits of choosing third-party tested supplements:

  • Verified ingredient list
  • Confirmed potency
  • Tested for contaminants
  • Greater overall reliability

Not all good products will have third-party certification, however this kind of testing can provide extra confidence in the supplement’s quality.

Reading Labels

Understanding supplement labels can help you to make informed decisions. Look for clear information about ingredients and dosages. Be careful about products that have unclear or incomplete labels.

Key things to check on guggul supplement labels:

  • Amount of guggul extract per serving
  • Standardization of guggulsterones
  • Full list of ingredients, including fillers
  • Recommended dosage
  • Manufacturer contact information

Avoid products that make exaggerated health claims. Reputable companies will only claim scientifically supported benefits. If a health claim sounds too good to be true, it most likely is.


FAQ: Common Questions About Guggul Side Effects

What are the most common side effects of guggul?
The most common side effects include stomach upset, diarrhea, and skin rashes.[21] These effects are usually mild and often improve with continued use.

Can guggul interact with prescription medications?
Yes, guggul can interact with several medications. It may affect blood thinners and thyroid medicines.[22] Always consult your doctor before combining guggul with other drugs.

Is guggul safe for long-term use?
The long-term safety of guggul isn’t fully known.[23] Some studies have used it for several months without major issues. However, it’s best to use guggul under medical supervision for extended periods.

How long does it take for guggul side effects to appear?
Side effects can occur soon after starting guggul.[24] Most people notice any effects within the first few days or weeks of use. Some reactions might develop over longer periods.

What should I do if I experience side effects from guggul?
If you have mild side effects, try reducing your dose. For severe or persistent effects, stop taking guggul and consult a healthcare provider.

Can guggul cause weight gain?
Guggul isn’t typically associated with weight gain.[25] In fact, some people use it for potential weight loss benefits. However, individual responses can vary.

Are there any age restrictions for taking guggul?
There’s limited research on guggul use in children or older adults. It’s generally recommended for adult use. Consult a pediatrician before giving guggul to children.

Can guggul affect hormone levels?
Guggul might influence thyroid hormone levels.[26] It may also affect other hormones, but more research is needed. People with hormone-sensitive conditions should use caution.

Is it safe to take guggul with other herbal supplements?
Combining guggul with other supplements may lead to interactions. Research each supplement individually and consult a healthcare provider before mixing them.

How can I minimize the risk of side effects when taking guggul?
Start with a low dose and increase gradually. Take guggul with food to reduce stomach upset. Stay hydrated and monitor your body’s response closely.

Fact Check
Claim: Guggul is a substance derived from the resin of the Commiphora mukul tree, which is native to India and its surrounding regions.
Fact check: True. Guggul is derived from the resin of the Commiphora mukul tree, which is native to India.

Commiphora mukul, also known as the Indian bdellium tree, is the source of guggul resin and is native to arid regions of India, Pakistan, and Bangladesh.

Source: “Pharmacology and Phytochemistry of Oleo-Gum Resin of Commiphora wightii (Guggulu)” https://pubmed.ncbi.nlm.nih.gov/26587309/

Claim: This resin has been used in traditional Ayurvedic medicine for many centuries.
Fact check: True. Guggul has a long history of use in traditional Ayurvedic medicine.

Ayurvedic texts dating back over 2000 years mention guggul for its therapeutic properties.

Source: “The guggul for chronic diseases: ancient medicine, modern targets” https://pubmed.ncbi.nlm.nih.gov/19189646/

Claim: Historically, guggul was used by traditional healers to address a range of health issues including arthritis, skin problems, and for weight management.
Fact check: True. Traditional uses of guggul include addressing arthritis, skin problems, and weight management.

Ancient Ayurvedic practitioners used guggul for various conditions including joint pain, skin disorders, and obesity. These traditional uses have spurred modern research in these areas.

Source: “Pharmacology and Phytochemistry of Oleo-Gum Resin of Commiphora wightii (Guggulu)” https://pubmed.ncbi.nlm.nih.gov/26587309/

Claim: Contemporary research is now focused on understanding how guggul impacts cholesterol levels and inflammation in the body.
Fact check: True. Current research is exploring guggul’s effects on cholesterol and inflammation.

Modern studies are focusing on the potential lipid-lowering and anti-inflammatory effects of guggul and its components.

Source: “Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits” https://pubmed.ncbi.nlm.nih.gov/18078436/

Claim: The guggul tree is a small, thorny species that thrives in dry areas of India, producing a yellowish resin.
Fact check: True. The Commiphora mukul tree is small and thorny, found in dry regions of India, and produces a yellowish resin.

The description of the guggul tree matches botanical descriptions of Commiphora mukul, which is found in arid and semi-arid regions of India.

Source: “Pharmacology and Phytochemistry of Oleo-Gum Resin of Commiphora wightii (Guggulu)” https://pubmed.ncbi.nlm.nih.gov/26587309/

Claim: The harvested resin undergoes an extraction and purification process to create supplements.
Fact check: True. Guggul resin is processed to create supplements.

The crude resin is extracted and purified to isolate specific compounds like guggulsterones, which are used in supplement manufacturing.

Source: “Pharmacology and Phytochemistry of Oleo-Gum Resin of Commiphora wightii (Guggulu)” https://pubmed.ncbi.nlm.nih.gov/26587309/

Claim: Guggul is mentioned in Ayurvedic texts dating back 2000 years.
Fact check: True. Guggul has been referenced in ancient Ayurvedic texts.

Ancient Ayurvedic texts like the Sushruta Samhita and Charaka Samhita mention guggul’s medicinal uses, dating back to around 2000 years ago.

Source: “The guggul for chronic diseases: ancient medicine, modern targets” https://pubmed.ncbi.nlm.nih.gov/19189646/

Claim: Among these compounds, guggulsterones are the most extensively studied.
Fact check: True. Guggulsterones are the most studied active compounds in guggul.

Research has primarily focused on the guggulsterones due to their significant biological activity. Studies have focused on their effects on cholesterol and inflammation.

Source: “Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598962/

Claim: Scientists have conducted studies to examine the effects of guggul on cholesterol management and weight loss.
Fact check: True. Studies have investigated guggul’s effects on cholesterol and weight.

Numerous clinical and preclinical studies have explored guggul’s impact on lipid profiles and body weight, with varying results.

Source: “Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits” https://pubmed.ncbi.nlm.nih.gov/18078436/

Claim: Some research suggests it could lower total cholesterol and also reduce levels of LDL cholesterol, which is often referred to as ‘bad’ cholesterol.
Fact check: Potentially True, but evidence is mixed. Some studies suggest guggul may lower total and LDL cholesterol, while others do not.

Some studies have shown a reduction in total cholesterol and LDL levels with guggul use, however, the findings are not consistent across all research and more studies are needed.

Source: “Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study” https://pubmed.ncbi.nlm.nih.gov/19114224/

Claim: Some studies suggest that guggul might influence metabolism, which could potentially aid in weight management.
Fact check: Potentially True, but evidence is inconsistent. Some studies show guggul might affect metabolism and aid in weight loss, but more research is needed.

While some studies suggest guggul may impact metabolism and fat cell development, these findings have not been consistently replicated.

Source: “Cistanche promotes the adipogenesis of 3T3-L1 preadipocytes” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887766/

Claim: Digestive issues are a common side effect of guggul use. Some individuals experience stomach discomfort after taking it.
Fact check: True. Digestive issues like stomach discomfort are a reported side effect of guggul.

Guggul can cause gastrointestinal disturbances in some users. This is a common, but usually mild, side effect.

Claim: Some people develop skin reactions when using guggul. These can vary from mild rashes to more serious allergic reactions.
Fact check: True. Skin rashes and allergic reactions are reported side effects of guggul use.

Skin reactions can occur both with oral and topical guggul use. Allergic responses can range from minor rashes to severe reactions in some individuals.

Claim: Headaches and dizziness can sometimes occur with guggul use.
Fact check: True. Headaches and dizziness have been reported as side effects of guggul.

Although less common, some individuals may experience headaches or dizziness when using guggul supplements.

Claim: Some studies suggest that guggul might affect liver function.
Fact check: Potentially True, but requires caution. Some studies suggest that guggul may impact liver function.

While not a common side effect, liver function changes have been noted in some studies. More studies are needed to fully understand the effects and whether it could impact those with pre-existing liver conditions.

Claim: Pregnant women should not use guggul supplements.
Fact check: True. Guggul is contraindicated during pregnancy.

Due to the lack of research on its effects on fetal development, guggul use is not recommended during pregnancy.

Claim: Breastfeeding mothers should also avoid guggul.
Fact check: True. Guggul is not recommended for breastfeeding mothers.

The effects of guggul on infants through breast milk are not known and, therefore, it is best avoided during breastfeeding.

Claim: Guggul could potentially enhance the effects of blood-thinning drugs.
Fact check: True. Guggul may interact with blood-thinning medications.

Guggul may increase the risk of bleeding by enhancing the effects of anticoagulant drugs. Caution is advised for individuals on these medications.

Claim: Guggul may have an effect on thyroid hormone levels, which could interfere with thyroid medications.
Fact check: True. Guggul may affect thyroid hormone levels, which could impact thyroid medications.

Guggul might interfere with thyroid hormone levels and thereby interact with thyroid medications. Monitoring is recommended for individuals taking both.

Claim: Most studies have used between 25 and 125 mg of guggulsterones daily, which generally corresponds to 1000 to 2000 mg of guggul extract.
Fact check: True. Clinical studies on guggul commonly use doses in this range.

The dosage of guggulsterones and corresponding extract used in trials typically falls within the given range.

Claim: The most common side effects include stomach upset, diarrhea, and skin rashes.
Fact check: True. Stomach upset, diarrhea and skin rashes are among the most common side effects.

These are some of the more commonly reported side effects associated with guggul consumption.

Claim: Yes, guggul can interact with several medications. It may affect blood thinners and thyroid medicines.
Fact check: True. Guggul is known to interact with blood thinners and thyroid medications.

Guggul’s interaction with blood thinners can increase bleeding risk. It can also interfere with thyroid medications, requiring close monitoring.

Claim: The long-term safety of guggul isn’t fully known.
Fact check: True. Long-term safety data for guggul is lacking.

There is limited research on the long-term effects of guggul supplementation. More studies need to be conducted on prolonged usage.

Claim: Side effects can occur soon after starting guggul.
Fact check: True. Side effects can appear soon after initiating guggul supplementation.

Some individuals may experience side effects shortly after they begin to take guggul.

Claim: Guggul isn’t typically associated with weight gain.
Fact check: True. Guggul is not typically associated with weight gain.

Most research suggests that guggul does not cause weight gain and some studies are exploring if it might help with weight loss.

Claim: Guggul might influence thyroid hormone levels.
Fact check: True. Guggul might impact thyroid hormones.

Research suggests guggul may have some effect on thyroid hormone levels, and people taking thyroid medications need to be aware of this potential interaction.


Medically reviewed and fact checked

Colors Nutrition does not provide medical advice, diagnosis, or treatment.