Takeaways
- MSM is a sulfur-containing compound found in some foods and supplements
- It may help reduce joint pain and inflammation
- MSM shows potential benefits for skin health and exercise recovery
- Typical dosages range from 1-6 grams per day
- MSM is generally considered safe with minimal side effects
- Consult a healthcare provider before starting MSM supplementation
What is MSM?
Methylsulfonylmethane, or MSM, is an organic sulfur compound.[1] It exists naturally in some foods in small amounts.[2] The body requires sulfur, which is found in MSM, for several vital functions.[3] Pure MSM is a white crystal that lacks any odor.[4]
Many individuals use MSM as a supplement to their diet. It is sold as a powder, in capsules, and as a liquid. Usually, supplement companies produce MSM in laboratories. The process begins with DMSO (dimethyl sulfoxide), which is then oxidized.[5]
MSM became a popular supplement during the 1990s.[6] Since then, scientists have been studying how it affects health. Although further research is necessary, initial findings suggest it may help with some conditions.[7]
Sources of MSM
MSM is found in small amounts in many of the foods we consume. Fresh fruits and vegetables contain MSM.[8] Some grains and drinks also have it.[9] However, cooking or processing food can reduce the amount of MSM it contains.[10]
Foods that naturally contain MSM include:
- Fresh fruits (especially berries)
- Raw vegetables
- Milk
- Coffee
- Tea
The MSM used in supplements is produced in a lab. Manufacturers create it through a multi-stage process that starts with petroleum or natural gas.[11] These raw materials are converted into DMSO.[12] Then the DMSO undergoes oxidation to produce MSM.[13]
Supplement forms of MSM typically offer much larger doses compared to what’s found in food. A common MSM supplement might provide 500-1000 mg in a single serving.[14] Foods, on the other hand, contain only very small amounts.
How MSM Works in the Body
In the body, MSM provides sulfur.[15] Sulfur is an element that is essential for life.[16] It is part of important molecules, like amino acids, which are the building blocks of proteins.[17]
The body uses the sulfur from MSM to make new cells.[18] It also plays a role in forming connective tissue such as cartilage, tendons, and ligaments.[19] This action may be how MSM supports joint health.
MSM interacts with various systems within the body:
System | Potential Effects of MSM |
---|---|
Joints | Reduces inflammation, supports cartilage health |
Skin | Promotes collagen production, improves elasticity |
Muscles | May reduce soreness, support recovery |
Immune | Could modulate immune responses |
Research indicates that MSM might reduce inflammation and act as an antioxidant.[20] These properties may explain some of its potential benefits. However, the specific ways MSM works are still being studied by scientists.
Potential Benefits of MSM
Joint Health
Many people use MSM to relieve joint pain.[21] Some studies suggest it may help reduce symptoms of osteoarthritis.[22] This condition involves the breakdown of cartilage in joints.
A study lasting 12 weeks investigated MSM’s effect on knee osteoarthritis. Those who took MSM reported having less pain and improved joint function.[23] This group also experienced a reduction in stiffness.
Another study examined the combination of MSM and glucosamine. This pairing resulted in reduced pain and swelling for those with knee osteoarthritis.[24] These effects were greater than those seen with glucosamine used alone.
MSM could work by decreasing inflammation in joints.[25] It also may help with the production of cartilage.[26] However, more research is needed to confirm these effects.
Skin Health
MSM shows potential for improving the health and look of skin.[27] The sulfur within MSM helps with collagen production.[28] Collagen is a protein that provides structure and flexibility to the skin.
Some research suggests MSM might help with certain skin issues, including:
- Rosacea
- Acne
- Aging skin
A small study looked at how MSM affects skin. Participants used a cream with MSM for a month. The results showed improvements in skin firmness and texture.[29]
Another study combined MSM with silymarin, an extract from milk thistle. This combination worked better than a placebo in reducing rosacea symptoms.[30]
MSM may help protect skin from damage caused by UV rays.[31] A laboratory study found it reduced inflammation resulting from UV exposure.[32] This suggests it might help prevent premature aging.
Exercise Recovery
Athletes and active people sometimes use MSM with the goal of speeding up their recovery and reducing muscle soreness.[33]
A study of young men exercising showed interesting results. Those who took MSM for 10 days before working out experienced less muscle soreness.[34] They also showed lower levels of markers associated with muscle damage.
Another study focused on runners. Those who took MSM for 3 weeks before running a half-marathon reported experiencing less muscle and joint pain.[35] They also felt less tired after the race.
MSM might help by reducing inflammation and oxidative stress.[36] These factors contribute to muscle soreness after exercise. More research is necessary to confirm these effects.
Other Potential Benefits
Researchers have explored the use of MSM for other health concerns. While the results are preliminary, some of these areas of interest include:
- Allergy relief
- Immune system support
- Hair and nail health
- Digestive issues
- Antioxidant effects
For instance, one study showed that MSM reduced allergy symptoms.[37] Those who took MSM for 30 days during allergy season reported an improvement in their upper and lower respiratory symptoms.[38]
Another study looked at how MSM might affect the immune system. It discovered that MSM might boost the body’s immune response.[39] This could help in fighting infections.
More research is needed in these areas. Scientists are still exploring how MSM impacts different aspects of health.
MSM Dosage and Administration
The appropriate dosage of MSM varies. It depends on why someone is taking it and their individual health. Most studies have used doses of between 1.5 and 6 grams each day.[40]
Here is a table showing common MSM dosages for different purposes:
Purpose | Typical Daily Dose |
---|---|
Joint health | 1.5 – 6 grams |
Skin health | 1 – 3 grams |
Exercise recovery | 1.5 – 3 grams |
Allergy relief | 2.6 grams |
These doses are often split into 2-3 servings to be taken throughout the day.[41] Some individuals start with a lower dose and gradually increase it over time.
MSM is sold in various forms. Powders, capsules, and tablets are common.[42] Some people prefer to mix powder into their drinks. Others find capsules more convenient.[43]
MSM products designed for topical use also exist. These include creams and lotions.[44] They are often used to promote skin health or ease localized joint pain.
Factors that can influence dosage include:
- Body weight
- Overall health status
- Reason for taking MSM
- Other medications or supplements
Always follow the directions on the product label regarding dosage. Consult a doctor for advice tailored to your needs.
Safety and Side Effects
Research suggests that MSM is generally safe for most people.[45] Studies have used doses as high as 6 grams daily without causing serious side effects.[46] However, some people might experience mild issues.[47]
Possible side effects of MSM supplementation include:
- Stomach discomfort
- Diarrhea
- Headache
- Fatigue
- Insomnia
- Itching
These effects are generally mild and often disappear with continued use.[48] Starting with a lower dose and gradually increasing it may help reduce the chance of side effects.
MSM could interact with some medications. People who are taking blood thinners should be careful.[49] MSM might potentially increase the effects of these drugs, which could increase the risk of bleeding.[50]
Women who are pregnant or breastfeeding should not use MSM.[51] There isn’t enough research to confirm whether it is safe in these situations.
People who are allergic to sulfa drugs should be careful when using MSM.[52] Although MSM does not contain sulfa, it does have sulfur. In rare cases, this might cause an allergic reaction.
As with any supplement, it’s a good idea to speak to a doctor before starting MSM. This is particularly important for people who have existing health conditions or take medications.
Who Should Consider MSM Supplementation?
MSM may be beneficial for specific groups of people. Consider MSM if you fit into one of these categories:
- People with joint pain or osteoarthritis
- Athletes or active individuals looking to support recovery
- Those seeking to improve skin health
- Individuals with seasonal allergies
- People looking for natural anti-inflammatory support
If you have chronic joint pain, MSM may be useful.[53] This is especially true if other supplements haven’t helped. Some people find that MSM works well when combined with glucosamine and chondroitin.[54]
Athletes might consider using MSM to help their recovery.[55] If you often experience muscle soreness after workouts, MSM could be helpful.[56] It may also benefit those training for long endurance events.
If you’re looking to improve your skin, MSM might be worth trying.[57] This applies to those who have specific skin conditions, as well as those who want to improve their skin’s overall appearance.
Those who suffer from allergies might find some relief with MSM.[58] If you struggle with seasonal allergies, MSM could be an option to explore.
Keep in mind that supplements are not magic solutions. They work best when paired with a healthy lifestyle. Eat a balanced diet, exercise often, and manage your stress. These practices support overall health and could improve the effectiveness of supplements.
Always consult with a healthcare provider before starting any new supplement. They can help you determine if MSM is a good choice for your particular situation.
How to Choose and Use MSM Supplements
Choosing a high-quality MSM supplement requires considering several things. Here are a few tips to guide your selection:
- Look for products from reputable manufacturers
- Check for third-party testing certifications
- Choose supplements with few or no additives
- Consider the form (powder, capsules, etc.) that works best for you
- Read customer reviews and ratings
When using MSM, consistency is key. Take it daily, following the directions, to get the best results.[59] Some people find that taking MSM with food helps reduce stomach discomfort.[60]
Begin with a lower dose and gradually increase it. This helps your body adjust and may lessen side effects.[61] Pay attention to how you feel and change your dose as needed.
Give MSM some time to work. Many studies lasted several weeks before showing significant results.[62] Don’t expect to see changes overnight. It’s a good idea to keep a journal to record any changes you observe.
MSM vs. Other Joint Health Supplements
MSM is one of many popular supplements used to promote joint health. Others include glucosamine and chondroitin. Here’s how they compare:
Supplement | Primary Function | Typical Daily Dose |
---|---|---|
MSM | Reduces inflammation, supports collagen | 1.5 – 6 grams |
Glucosamine | Supports cartilage formation | 1.5 – 3 grams |
Chondroitin | Promotes water retention in cartilage | 800 – 1200 mg |
Some products combine these supplements. The idea behind this is that they might work more effectively together.[63] For example, one study found that a combination of MSM and glucosamine was more effective for osteoarthritis than glucosamine alone.[64]
Each person responds to supplements differently. What works well for one person might not work for another.[65] You might need to try a few different options to find out what works best for you.
Frequently Asked Questions
Is MSM the same as DMSO?
Can MSM help with allergies?
How long does it take for MSM to work?
Is MSM safe for pets?
Conclusion
MSM shows promise as a supplement for various health concerns.[78] Its potential benefits for joint health, skin, and exercise recovery are interesting.[79] However, further research is required to fully understand its effects.
If you’re thinking about using MSM, include it as part of an overall approach to health. Combine it with a balanced diet, regular physical activity, and stress management. These practices are the basis of good health.
Keep in mind that supplements affect each person differently. What works well for one person may not work for another. Be patient and give MSM time to work. Track any changes you notice.
Always prioritize safety when trying new supplements. Begin with a lower dose and gradually increase it. If you have any health conditions or take medications, talk to your doctor first.
MSM is only one tool within the vast world of nutrition and supplementation. Stay curious, keep learning, and make well-informed decisions about your health. With the right approach, supplements like MSM can be beneficial additions to a healthy lifestyle.
MSM is a naturally occurring compound that contains sulfur, which is essential for various bodily functions.
Foods like fruits, vegetables, grains, and some beverages contain trace amounts of MSM, but processing and cooking can reduce these levels.
Sulfur plays a role in protein synthesis, enzyme activity, and the structure of connective tissue. MSM provides sulfur to the body.
The physical characteristics of MSM include its crystalline form, white color, and lack of odor.
The industrial production of MSM usually begins with DMSO which then undergoes oxidation to become MSM.
MSM started gaining traction as a nutritional supplement in the 1990s for its potential health benefits.
Research has indicated the potential benefits of MSM but more research is required to validate these.
Fruits and vegetables contain trace amounts of MSM, but these levels can vary depending on growing conditions and processing methods.
Small quantities of MSM may be present in some grains and beverages in trace amounts.
MSM is a volatile compound and can be lost during heating and processing.
The industrial synthesis of MSM often utilizes petroleum or natural gas as the foundation for producing DMSO, which is then oxidized to make MSM.
The conversion of raw materials into DMSO is an essential step in the process of MSM synthesis.
Oxidation of DMSO is the final step in the laboratory synthesis of MSM.
The dosages found in MSM supplements are much higher than what would be found naturally in food.
The primary way MSM works in the body is by delivering sulfur, an essential element.
Sulfur plays a role in many cellular processes and is an integral part of biomolecules.
Sulfur is present in amino acids like cysteine and methionine, which are necessary for protein production.
Sulfur plays a key role in various cellular functions, including the formation of new cells.
Sulfur is a necessary component in the creation of collagen and other proteins found in connective tissues.
Research suggests that MSM may have properties that reduce inflammation and oxidative stress. However, more research is needed to confirm the mechanisms and efficacy.
Source: “Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement” https://pubmed.ncbi.nlm.nih.gov/28300758/
MSM has become a popular choice as a supplemental approach for people looking to relieve joint discomfort.
Multiple studies have looked at MSM’s potential for alleviating the symptoms of osteoarthritis.
This study showed reductions in pain and increases in function in participants who took MSM.
Research has found that the combination of MSM and glucosamine is more effective than just glucosamine alone in managing pain and swelling in knee osteoarthritis.
Source: “Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial” https://pubmed.ncbi.nlm.nih.gov/26684635/
One proposed mechanism for MSM’s effect on joint pain is its anti-inflammatory actions.
Studies suggest that MSM may have a potential role in cartilage formation, although more research is needed to fully understand this.
Early research suggests that MSM may offer benefits in promoting healthy skin.
Sulfur is a necessary component for the synthesis of collagen, which is a protein essential for skin structure.
One study observed improved skin firmness and texture when using an MSM topical cream for a month.
Research has found that combining MSM with silymarin improves rosacea symptoms more than placebo.
Laboratory studies have shown that MSM may reduce inflammation from UV exposure, suggesting it may help with protection and anti-aging.
Studies in a laboratory setting found that MSM reduces inflammation caused by UV rays, suggesting it might be helpful for protection against UV skin damage.
MSM is sometimes used by athletes to reduce post-exercise muscle soreness and promote faster recovery.
Studies on athletes taking MSM before exercise found reduced muscle soreness following workouts.
This study found that MSM supplementation resulted in less muscle and joint pain and fatigue after a race.
Source: “Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial” https://pubmed.ncbi.nlm.nih.gov/28736511/
It is proposed that MSM may alleviate post exercise pain by decreasing inflammation and the effects of oxidative stress.
MSM may have a potential in managing some allergy symptoms, such as respiratory symptoms.
Studies on seasonal allergy sufferers have shown that MSM supplementation can improve both upper and lower respiratory symptoms.
Studies suggest MSM may have a role in modulating the immune system, but the results are limited and more research is needed.
Research has often used MSM doses ranging from 1.5 grams to 6 grams in the studies examining its potential benefits.
Dividing dosages of MSM can help maintain stable levels in the body and may help to reduce possible GI side effects.
MSM supplements are available in several forms, providing a variety of options depending on individual preferences.
MSM powder allows for easy mixing into beverages while capsules are a convenient, no-prep option.
MSM can be found in topical creams and lotions for application to the skin.
MSM is considered generally safe with a low risk of serious side effects at common supplemental doses.
Source: “Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement” https://pubmed.ncbi.nlm.nih.gov/28300758/
Clinical studies have used 6 grams per day with only mild side effects, demonstrating a high level of safety in human subjects.
While MSM is generally well-tolerated, some people may experience mild side effects like bloating or diarrhea.
Side effects of MSM are usually mild and may lessen or resolve with continued use as the body adjusts.
MSM may potentiate the action of blood thinners which could increase the risk of bleeding.
MSM may interact with anticoagulant medications and could increase the risk of hemorrhage, if not monitored.
The safety of MSM during pregnancy and breastfeeding has not been fully researched and it’s recommended to avoid its use during these times.
Although MSM does not contain sulfa drugs, people with an allergy to sulfa medication should be careful because it does contain sulfur.
MSM is used as a dietary supplement to reduce the inflammation and pain associated with joint conditions.
MSM is sometimes used in combination with other joint health supplements such as glucosamine and chondroitin.
Athletes may find MSM beneficial in reducing exercise-induced muscle damage and speeding recovery.
MSM has been shown in studies to lessen the severity of muscle soreness following exercise.
MSM has potential benefits for skin health, and people may consider it for improving its condition.
There is limited research to suggest MSM might help with allergy symptoms, but more robust studies are required.
MSM is most effective when used regularly and consistently, as directed on the packaging.
Taking MSM with meals may help minimize potential gastrointestinal side effects.
Gradually increasing the dosage of MSM helps the body adjust and may mitigate any potential adverse effects.
Many studies on the effects of MSM have shown that results take several weeks to become noticeable.
The thought behind combination supplements is that their ingredients have synergistic effects that make them more effective when taken together.
A study showed MSM and glucosamine supplementation together is more effective than taking glucosamine alone for osteoarthritis symptoms.
Source: “Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial” https://pubmed.ncbi.nlm.nih.gov/26684635/
Individual differences in physiology, genetics, and lifestyle can cause varied responses to supplements.
DMSO and MSM are related but different molecules. DMSO is converted into MSM through oxidation.
MSM is formed through the oxidation of DMSO during production.
Industrial production of MSM relies on the oxidation of DMSO to create MSM.
Although DMSO is a precursor to MSM, both molecules have different chemical structures, applications and safety profiles.
Studies suggest that MSM may play a role in managing allergy symptoms, but further research is needed.
A study showed an improvement in upper and lower respiratory symptoms from seasonal allergies with 30 day use of MSM.
The time frame for seeing results from MSM varies, with some reporting changes in a few weeks and others requiring a month or more.
Dosage, individual metabolic rates, and the particular condition being addressed can impact the timeline for noticing results from MSM supplementation.
MSM is often used in the treatment of musculoskeletal and inflammatory conditions in horses and dogs.
MSM has been used to help manage pain and inflammation associated with joint or skin problems in pets.
MSM may amplify the effects of blood thinners, increasing the risk of bleeding.
MSM may potentially increase the effects of blood thinning medications which may increase risk of bleeding.
MSM is being explored for its effects on a variety of health problems and has demonstrated potential in some studies.
The potential uses of MSM for joint health, skin, and exercise recovery are areas of interest for those looking for supplements.