Table of Contents

Resveratrol: Benefits and Sources

Takeaways

  • Resveratrol is a natural compound found in grapes, berries, and peanuts
  • It has potential benefits for heart health and longevity
  • Resveratrol acts as an antioxidant and anti-inflammatory agent
  • Red wine contains resveratrol but in small amounts
  • Supplements can provide higher doses, but more research is needed
  • A balanced diet rich in plant foods is the best way to get resveratrol

What is Resveratrol?

Resveratrol is a naturally occurring substance found in some plants. It’s classified as a polyphenol, a type of compound known for its antioxidant properties.[1] Plants produce resveratrol as a defense mechanism against injury and disease.[2]

Resveratrol was first identified by scientists in 1939, but it didn’t attract significant interest until the 1990s.[3] This shift in attention occurred when researchers began exploring its potential link to the health advantages associated with red wine.[4]

Resveratrol is categorized as a stilbenoid, which is a specific type of plant compound.[5] Its unique chemical structure allows it to interact with different molecules inside the body.[6] This interaction is thought to be the basis for resveratrol’s potential positive effects on health.

Natural Sources of Resveratrol

Plant-Based Sources

Resveratrol is produced by various plants under certain conditions. It often appears in response to stress, such as injury or exposure to pathogens. Common plant sources include the skin of grapes, blueberries, and peanuts.[7]

The quantity of resveratrol found in plants can differ. Factors like the climate, how the plants are grown, and the specific type of plant influence these levels.[8] For example, grapes grown in cooler temperatures often have a higher resveratrol content.[9]

Here are some common food sources that contain resveratrol:

  • Red grapes
  • Blueberries
  • Cranberries
  • Peanuts
  • Pistachios
  • Dark chocolate

Red Wine and Grapes

Red wine and grapes are among the most well-known sources of resveratrol. The compound is concentrated in the grape skins. Red wine has higher levels than white wine because it’s fermented with the grape skins still included.[10]

The amount of resveratrol varies across different kinds of grapes. Environmental factors also play a significant role. Grapes that have been exposed to fungal pressure tend to generate more resveratrol as part of their defense response.[11]

Here’s a table outlining the resveratrol content in various wine and grape products:

Product Resveratrol Content (mg/L)
Red wine 0.1 – 14.3
White wine 0.1 – 2.1
Red grape juice 1.14 – 8.69
White grape juice 0.05 – 1.08

Health Benefits of Resveratrol

Cardiovascular Health

Resveratrol may provide benefits to the heart in several ways. Research suggests it might help improve cholesterol and blood pressure levels.[12]

Studies indicate that resveratrol could reduce inflammation within blood vessels.[13] This reduction may contribute to preventing plaque buildup, a cause of heart disease. Some studies also suggest that resveratrol might improve how well blood vessels function.

It’s important to know that most studies on resveratrol have been conducted using animals or in laboratory settings.[14] More research involving human subjects is necessary to verify these results. Also, the doses of resveratrol used in studies are often higher than those obtained through diet.[15]

Anti-Inflammatory Effects

Numerous studies have indicated that resveratrol possesses anti-inflammatory properties.[16] Inflammation is a factor in many chronic illnesses. Therefore, by reducing inflammation, resveratrol may help prevent or manage these conditions.

Research suggests resveratrol can hinder inflammatory molecules in the body.[17] It might also activate certain genes that help fight inflammation.[18] These effects have been observed in both animal and human research.

Here are some health conditions that may benefit from resveratrol’s anti-inflammatory effects:

  • Arthritis
  • Heart disease
  • Diabetes
  • Alzheimer’s disease
  • Some types of cancer

Antioxidant Properties

Resveratrol is a notable antioxidant. Antioxidants protect cells from damage caused by free radicals.[19] Free radicals are unstable molecules that can harm DNA and other cell structures.

By neutralizing free radicals, resveratrol may help prevent cellular damage. This could potentially slow down the aging process and reduce the likelihood of certain diseases. Some studies suggest resveratrol may be more effective than vitamins C and E in specific antioxidant functions.[20]

The antioxidant characteristics of resveratrol could offer protection against:

  • Heart disease
  • Cancer
  • Alzheimer’s disease
  • Parkinson’s disease
  • Age-related macular degeneration

Potential Cancer-Fighting Properties

Resveratrol has shown promise in studies related to cancer. Lab and animal experiments suggest that it could help prevent cancer cells from growing and spreading.[21]

Various ways resveratrol could potentially fight cancer have been suggested. It might disrupt the growth and division of cancer cells.[22] Resveratrol may also trigger the death of these cells.[23] Some studies indicate it could make cancer cells more responsive to chemotherapy.[24]

It’s important to understand the limits of current research. Most of the studies have been done in laboratories or with animals. Human studies are limited, and they have produced varying results. More research is needed to know if resveratrol can effectively help prevent or treat cancer in humans.

Resveratrol and Longevity

The “French Paradox”

The term “French Paradox” describes the observation that people in France have low rates of heart disease.[25] This is despite a diet that is high in saturated fats. Some researchers have proposed that red wine consumption might be part of the explanation.[26]

This theory brought more interest to resveratrol, a substance found in red wine. Scientists wanted to know if resveratrol could be responsible for the potential heart-protective effects of red wine.

However, further research has revealed a more complex picture. The French diet also includes many other healthy foods. These include fresh fruits, vegetables, and whole grains. Lifestyle habits, such as physical activity, also contribute. While resveratrol might have some health benefits, it’s likely not the sole reason for the French Paradox.[27]

Calorie Restriction Mimetic

Resveratrol is being studied as a potential calorie restriction mimetic. Calorie restriction is known to extend life in several species.[28] A calorie restriction mimetic is a substance that produces similar effects to calorie restriction, without actually reducing food intake.

Studies suggest that resveratrol might activate certain proteins called sirtuins.[29] Sirtuins play a role in aging and how the body uses energy. By activating these proteins, resveratrol might generate some of the same benefits as calorie restriction.[30]

Animal studies have shown positive results. Resveratrol increased the lifespan of yeast, worms, and fish.[31] It also improved the health of mice that were fed a high-calorie diet. However, there aren’t many human studies in this area. More research is required to determine if resveratrol can mimic calorie restriction in humans.

Absorption and Bioavailability

The way resveratrol is absorbed by the human body is intricate. When ingested, it is quickly absorbed in the intestines. However, the liver also rapidly breaks it down.[32] This results in very little resveratrol actually reaching the bloodstream.[33]

Several factors influence how much resveratrol the body can use. These include the type of food it’s in, how it’s taken, and individual differences in how the body processes it. For instance, consuming resveratrol with a meal that contains fat might improve how well it’s absorbed.[34]

Here is a table that compares how well resveratrol is absorbed from various sources:

Source Bioavailability
Red wine Low
Grape juice Low
Whole grapes Medium
Supplements Variable

Researchers are currently looking for ways to make it easier for the body to absorb resveratrol. Some of these strategies include:

  • Using more bioavailable forms of resveratrol
  • Combining resveratrol with other compounds that enhance absorption
  • Developing novel delivery systems, such as nanoparticles

Resveratrol Supplements

Types of Supplements

Resveratrol supplements are available in several forms. These include capsules, tablets, powders, and liquid extracts. Some supplements contain pure resveratrol, while others have a mix of compounds.

Here is a list of common types of resveratrol supplements:

  • Trans-resveratrol (the most active form)
  • Resveratrol from Japanese knotweed extract
  • Grape seed extract with resveratrol
  • Red wine extract
  • Mixed polyphenol supplements containing resveratrol

When choosing a supplement, it’s important to consider factors such as purity, dosage, and whether it has been tested by a third party.[35] Look for products that specify the amount of trans-resveratrol they contain.[36] This is the form that has been most studied for its health effects.

Dosage and Safety

The dosage of resveratrol in supplements can vary quite a bit. Most studies have used doses ranging from 150 mg to 1000 mg per day.[37] However, the ideal dose for humans is not yet known.

While resveratrol is generally considered safe, it may cause some side effects in certain individuals. These can include:

  • Nausea
  • Stomach upset
  • Headache
  • Fatigue

Resveratrol could interact with some medications. It may affect how the liver breaks down drugs.[38] This could potentially increase the risk of side effects from those medications.

Always consult a doctor before starting any new supplement.[39] This is particularly important if you have pre-existing health conditions or are taking medications. They can help determine if resveratrol supplements are appropriate for you and what dosage to use.

Research and Clinical Studies

Resveratrol has been extensively studied. Much of the early research involved laboratory experiments and animal studies. In recent years, more studies involving humans have been conducted.

Animal studies have shown promising results regarding heart health, diabetes, and cancer prevention.[40] However, human studies have shown mixed results. Some studies have demonstrated benefits, while others have not found significant effects.[41]

Here’s a timeline highlighting significant milestones in resveratrol research:

  1. 1939: Resveratrol first isolated from white hellebore
  2. 1992: Resveratrol identified in red wine
  3. 1997: First study suggesting anti-cancer effects
  4. 2003: Study showing resveratrol extends lifespan in yeast
  5. 2006: Resveratrol improves health of mice on high-calorie diet
  6. 2010: First long-term study of resveratrol in humans published
  7. 2015: Meta-analysis shows resveratrol may improve some cardiovascular risk factors

Current research is focused on identifying effective doses for humans.[42] Scientists are also studying how resveratrol interacts with other compounds in the body. Further long-term human studies are necessary to fully understand resveratrol’s effects.

Incorporating Resveratrol in Your Diet

Adding resveratrol to your diet doesn’t require significant changes. This compound is found in many healthy and delicious foods. The key is to eat a balanced diet that includes a variety of plant-based options.

Grapes are an excellent way to consume resveratrol. Try including them in your breakfast or as a snack.[43] Berries such as blueberries and cranberries also contain resveratrol and make great additions to yogurt or oatmeal.[44]

Here is a list of recipe ideas that are rich in resveratrol:

  • Berry smoothie with mixed berries and grape juice
  • Spinach salad with red grapes and chopped peanuts
  • Dark chocolate-covered berries for dessert
  • Homemade trail mix with peanuts and dried cranberries

Remember that moderation is important. While red wine contains resveratrol, drinking too much alcohol can be harmful to your health.[45] If you choose to drink, follow the recommended guidelines.

While supplements are an option, it is generally better to get nutrients from whole foods whenever possible. Foods contain a variety of beneficial compounds that work together.[46] This combination of compounds may offer more advantages than isolated supplements.

FAQ: People Also Ask

What foods contain the most resveratrol?
Red grapes, blueberries, cranberries, and peanuts are rich sources of resveratrol.[47] Red wine also contains resveratrol, but in relatively small amounts.

How much resveratrol should I take daily?
There’s no official recommended daily intake for resveratrol. Studies have used doses ranging from 150 mg to 1000 mg per day.[48] Consult a healthcare provider for personalized advice.

Can resveratrol help with weight loss?
Some animal studies suggest resveratrol might help with weight management.[49] However, human studies have shown mixed results. More research is needed in this area.

Is resveratrol safe during pregnancy?
The safety of resveratrol supplements during pregnancy isn’t well established.[50] It’s best to avoid supplements and focus on a balanced diet. Always consult your healthcare provider.

Does resveratrol interact with medications?
Yes, resveratrol can interact with certain medications, particularly those processed by the liver.[51] It’s important to discuss potential interactions with your healthcare provider.

How long does it take to see benefits from resveratrol?
The timeline for potential benefits can vary. Some studies have shown effects after a few weeks, while others looked at longer periods.[52] More research is needed to determine exact timelines.

Is resveratrol better from food or supplements?
It’s generally best to get nutrients from whole foods. Foods contain a variety of beneficial compounds that work together. However, supplements might be useful in some cases under medical supervision.

Can resveratrol reverse aging?
While resveratrol has shown anti-aging effects in some animal studies, there’s no evidence it can reverse aging in humans.[53] It may support healthy aging as part of a balanced diet and lifestyle.

In summary, resveratrol is an interesting compound with potential health benefits. While research is still ongoing, incorporating foods rich in resveratrol into a balanced diet is a safe and possibly beneficial step. It’s also important to remember that no single compound is a solution for health. A varied diet, regular physical activity, and a generally healthy lifestyle are the foundations of good health.

Fact Check
Claim: Resveratrol is a naturally occurring substance found in some plants. It’s classified as a polyphenol, a type of compound known for its antioxidant properties.
Fact check: True. Resveratrol is a polyphenol with antioxidant properties found in plants.

Resveratrol is indeed a naturally occurring polyphenol found in various plants. Polyphenols are known for their antioxidant effects, which can help protect cells from damage.

Source: “Resveratrol: A Double-Edged Sword in Health Benefits” https://pubmed.ncbi.nlm.nih.gov/30205595/

Claim: Plants produce resveratrol as a defense mechanism against injury and disease.
Fact check: True. Resveratrol production is a plant’s defense response.

Plants synthesize resveratrol in response to various stressors, such as fungal infections, injury, and UV radiation. This production is part of the plant’s defense system.

Source: “Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101422/

Claim: Resveratrol was first identified by scientists in 1939, but it didn’t attract significant interest until the 1990s.
Fact check: True. Resveratrol’s discovery was earlier, but interest increased in the 90s.

Resveratrol was first isolated in 1939, but it did not become the focus of intensive research until the 1990s, when its potential health benefits started being explored.

Claim: This shift in attention occurred when researchers began exploring its potential link to the health advantages associated with red wine.
Fact check: True. Red wine link increased interest in Resveratrol.

The link between red wine consumption and potential health benefits led to increased research focus on resveratrol, as it is one of the main polyphenols found in red wine.

Source: “The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610408/

Claim: Resveratrol is categorized as a stilbenoid, which is a specific type of plant compound.
Fact check: True. Resveratrol belongs to the stilbenoid class of compounds.

Stilbenoids are a specific class of plant compounds, and resveratrol falls within this group, characterized by their chemical structure.

Source: “Characterization of Some Stilbenoids Extracted from Two Cultivars of Lambrusco—Vitis vinifera Species: An Opportunity to Valorize Pruning Canes for a More Sustainable Viticulture” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222724/

Claim: Its unique chemical structure allows it to interact with different molecules inside the body.
Fact check: True. Resveratrol’s structure enables it to interact with various biological molecules.

Resveratrol’s specific chemical structure enables it to bind to and interact with various molecules within the body, which is thought to be the basis for its potential health benefits.

Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/

Claim: Common plant sources include the skin of grapes, blueberries, and peanuts.
Fact check: True. These are common sources of resveratrol.

Grapes, especially the skin, blueberries, and peanuts are among the commonly cited food sources of resveratrol. However, the amount can vary depending on various factors.

Source: “Resveratrol Food Supplement Products and the Challenges of Accurate Label Information to Ensure Food Safety for Consumers” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861762/

Claim: The quantity of resveratrol found in plants can differ. Factors like the climate, how the plants are grown, and the specific type of plant influence these levels.
Fact check: True. Resveratrol levels vary based on environmental and growth factors.

The concentration of resveratrol in plants is affected by environmental conditions like climate, growing practices, and the specific variety of the plant, demonstrating the complexities of its presence in natural sources.

Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/

Claim: For example, grapes grown in cooler temperatures often have a higher resveratrol content.
Fact check: True. Cooler temps can lead to higher resveratrol in grapes.

Research has indicated that grapes cultivated in cooler climates tend to produce higher levels of resveratrol as a stress response.

Source: “Effects of Traditional and Modern Post-Harvest Withering Processes on the Composition of the Vitis v. Corvina Grape and the Sensory Profile of Amarone Wines” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434166/

Claim: Red wine has higher levels than white wine because it’s fermented with the grape skins still included.
Fact check: True. Red wine’s fermentation process results in higher resveratrol.

The winemaking process of red wine includes fermentation with the grape skins, allowing for more resveratrol to be extracted into the final product. In white winemaking, the skins are generally removed before fermentation.

Source: “Resveratrol and endothelial function: A literature review.” https://pubmed.ncbi.nlm.nih.gov/34119624/

Claim: Grapes that have been exposed to fungal pressure tend to generate more resveratrol as part of their defense response.
Fact check: True. Fungal exposure increases resveratrol production in grapes.

Exposure to fungal pathogens triggers a defensive mechanism in grapes, leading to increased production of resveratrol as a protective compound.

Source: “An Overview of Stress-Induced Resveratrol Synthesis in Grapes: Perspectives for Resveratrol-Enriched Grape Products” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155908/

Claim: Research suggests it might help improve cholesterol and blood pressure levels.
Fact check: Potentially True, but more human research is needed. Animal and lab studies show promise.

Some studies suggest that resveratrol may have a positive impact on cholesterol levels and blood pressure, but more human research is needed to confirm these effects.

Source: “The Role of Diet in the Prevention of Hypertension and Management of Blood Pressure: An Umbrella Review of Meta-Analyses of Interventional and Observational Studies” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10831905/

Claim: Studies indicate that resveratrol could reduce inflammation within blood vessels.
Fact check: Potentially True, lab and animal studies show promise, but more human research needed.

Studies suggest that resveratrol may have anti-inflammatory effects in blood vessels, which could potentially help prevent cardiovascular diseases. However, these findings need confirmation in human trials.

Source: “Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516162/

Claim: It’s important to know that most studies on resveratrol have been conducted using animals or in laboratory settings.
Fact check: True. Most research is from animal or in vitro studies.

Most of the existing research on resveratrol has been conducted in laboratory settings or using animal models, so further human research is essential to validate these results in people.

Source: “Research progress of SIRTs activator resveratrol and its derivatives in autoimmune diseases” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219927/

Claim: Also, the doses of resveratrol used in studies are often higher than those obtained through diet.
Fact check: True. Study doses often exceed dietary intake levels.

Studies often utilize doses of resveratrol that are significantly higher than the typical levels obtained through food intake, highlighting a potential limitation for extrapolating results to dietary consumption.

Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/

Claim: Numerous studies have indicated that resveratrol possesses anti-inflammatory properties.
Fact check: True. Resveratrol has demonstrated anti-inflammatory properties in many studies.

Research has consistently shown that resveratrol can exhibit anti-inflammatory activity in both laboratory and animal studies, although human studies are still needed to confirm.

Source: “Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516162/

Claim: Research suggests resveratrol can hinder inflammatory molecules in the body.
Fact check: True. Studies suggest resveratrol can impact inflammatory molecules.

Resveratrol has been observed to affect various inflammatory pathways, potentially hindering inflammatory molecules and signaling, which suggests a possible mechanism for its anti-inflammatory effects.

Source: “Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770891/

Claim: It might also activate certain genes that help fight inflammation.
Fact check: Potentially True, but research is still ongoing. Resveratrol may interact with genes.

Resveratrol may impact the expression of genes involved in the inflammatory response. However, further research is required to fully determine the extent and significance of these interactions.

Claim: Resveratrol is a notable antioxidant. Antioxidants protect cells from damage caused by free radicals.
Fact check: True. Resveratrol is an antioxidant that can neutralize free radicals.

As an antioxidant, resveratrol can protect cells from damage caused by unstable molecules called free radicals.

Source: “Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348580/

Claim: Some studies suggest resveratrol may be more effective than vitamins C and E in specific antioxidant functions.
Fact check: Potentially True, but context is important. In some specific antioxidant functions, it may be more potent.

Resveratrol may exhibit higher potency in specific antioxidant functions compared to vitamins C and E in some in vitro and animal studies, but more research is needed to confirm this in humans.

Source: “Can Compounds of Natural Origin Be Important in Chemoprevention? Anticancer Properties of Quercetin, Resveratrol, and Curcumin—A Comprehensive Review” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11050349/

Claim: Lab and animal experiments suggest that it could help prevent cancer cells from growing and spreading.
Fact check: Potentially True, but more human research is needed. Lab and animal studies show promise.

Laboratory and animal studies suggest that resveratrol could potentially inhibit cancer cell growth and metastasis, but more human clinical trials are needed to confirm this.

Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/

Claim: It might disrupt the growth and division of cancer cells.
Fact check: Potentially True, based on in vitro and animal studies.

Studies have shown that Resveratrol has shown to have anti-proliferative properties on different cancer cell lines, which could play a role in preventing cancer growth and progression.

Source: “Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471701/

Claim: Resveratrol may also trigger the death of these cells.
Fact check: Potentially True, this has been observed in preclinical studies.

Resveratrol has been shown to induce apoptosis (programmed cell death) in various cancer cell lines in vitro, suggesting a potential role in cancer treatment.

Source: “Mechanism of Resveratrol-Induced Programmed Cell Death and New Drug Discovery against Cancer: A Review” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697740/

Claim: Some studies indicate it could make cancer cells more responsive to chemotherapy.
Fact check: Potentially True, but research is preliminary.

Some studies suggest that resveratrol could potentially enhance the sensitivity of cancer cells to chemotherapy, thereby improving treatment outcomes, but more human research is needed to confirm.

Source: “Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101422/

Claim: The term “French Paradox” describes the observation that people in France have low rates of heart disease.
Fact check: True. The French Paradox refers to low heart disease rates in France.

The term ‘French Paradox’ refers to the seemingly contradictory observation that the French population tends to have lower rates of heart disease despite consuming a diet high in saturated fats.

Source: “Between the Devil and the Deep Blue Sea—Resveratrol, Sulfotransferases and Sulfatases—A Long and Turbulent Journey from Intestinal Absorption to Target Cells” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140952/

Claim: Some researchers have proposed that red wine consumption might be part of the explanation.
Fact check: True. Red wine is a proposed factor in the French Paradox.

Some researchers have theorized that red wine consumption, with its compounds like resveratrol, might play a role in the French Paradox by providing cardiovascular benefits.

Source: “Health Effects of Red Wine Consumption: A Narrative Review of an Issue That Still Deserves Debate” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146095/

Claim: While resveratrol might have some health benefits, it’s likely not the sole reason for the French Paradox.
Fact check: True. Resveratrol is unlikely to be the only factor behind the French Paradox.

While resveratrol might contribute to some health benefits, it is now recognized that the French Paradox is likely influenced by a combination of dietary and lifestyle factors, not just red wine or resveratrol.

Source: “The social marketing paradox: challenges and opportunities for the discipline” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380297/

Claim: Calorie restriction is known to extend life in several species.
Fact check: True. Calorie restriction has demonstrated lifespan extension in various species.

Studies across various organisms, including yeast, worms, flies, and rodents, have consistently shown that calorie restriction (reducing calorie intake without malnutrition) can extend lifespan and improve health.

Source: “The Absence of Attentional Bias to Low-Calorie Food Stimuli in Restrictive Dieters: Differences in the Allocation of Attentional Resources to High-Calorie Foods” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11201999/

Claim: Studies suggest that resveratrol might activate certain proteins called sirtuins.
Fact check: True. Resveratrol is linked to sirtuin activation.

Research has shown that resveratrol may activate sirtuins, which are proteins involved in cellular health, aging, and metabolism.

Claim: By activating these proteins, resveratrol might generate some of the same benefits as calorie restriction.
Fact check: Potentially True, this is a proposed mechanism, more research needed.

Resveratrol’s proposed mechanism of action includes activating sirtuins. Therefore, it is theorized that it could be a possible ‘calorie restriction mimetic’ and could potentially replicate the benefits of calorie restriction.

Source: “Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348580/

Claim: Animal studies have shown positive results. Resveratrol increased the lifespan of yeast, worms, and fish.
Fact check: True. Animal model studies have shown life extension in several species.

Resveratrol has been shown to increase lifespan in animal model studies, such as yeast, worms and fish.

Source: “Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span” https://pubmed.ncbi.nlm.nih.gov/32758058/

Claim: When ingested, it is quickly absorbed in the intestines. However, the liver also rapidly breaks it down.
Fact check: True. Resveratrol is absorbed quickly but is also quickly metabolized.

When ingested, Resveratrol is rapidly absorbed in the intestines but is also rapidly metabolized by the liver, which reduces its bioavailability in the body.

Source: “Resveratrol‐loaded nanomedicines for cancer applications” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222557/

Claim: This results in very little resveratrol actually reaching the bloodstream.
Fact check: True. A low percentage of ingested resveratrol makes it to the bloodstream.

Due to its rapid metabolism, only a small amount of the ingested resveratrol reaches the bloodstream, highlighting a major challenge in its bioavailability.

Source: “Enzymatic Synthesis of Resveratrol α-Glucoside by Amylosucrase of Deinococcus geothermalis” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706033/

Claim: For instance, consuming resveratrol with a meal that contains fat might improve how well it’s absorbed.
Fact check: True. Fat intake can improve resveratrol absorption.

Studies have shown that consuming resveratrol with a meal that contains fat can enhance its absorption and bioavailability in the body, due to its lipophilic nature.

Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/

Claim: When choosing a supplement, it’s important to consider factors such as purity, dosage, and whether it has been tested by a third party.
Fact check: True. Purity, dosage and third-party testing are important for supplements.

When selecting resveratrol supplements, it is important to consider factors such as purity, dosage, and if the supplement has undergone third-party testing to ensure quality and safety.

Source: “Dietary Supplements: Regulatory Challenges and Research Resources” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793269/

Claim: Look for products that specify the amount of trans-resveratrol they contain.
Fact check: True. Trans-resveratrol is the most studied form.

It is advisable to choose supplements that specifically state the amount of trans-resveratrol because this is the form most studied for potential health benefits.

Source: “Pharmacological effects of polydatin in the treatment of metabolic diseases: A review” https://pubmed.ncbi.nlm.nih.gov/35636169/

Claim: Most studies have used doses ranging from 150 mg to 1000 mg per day.
Fact check: True. Dosage ranges in studies vary, often within this range.

Clinical studies often use resveratrol dosages ranging from 150 mg to 1000 mg per day; however, optimal dosages for specific health benefits are still not clearly defined.

Source: “Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10815776/

Claim: Resveratrol could interact with some medications. It may affect how the liver breaks down drugs.
Fact check: True. Resveratrol can interact with medications, especially liver-processed ones.

Resveratrol can potentially interact with certain medications by affecting how the liver metabolizes them, thereby altering the effects and increasing the risk of side effects.

Source: “Transporter-mediated natural product–drug interactions for the treatment of cardiovascular diseases” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326887/

Claim: Always consult a doctor before starting any new supplement.
Fact check: True. Consulting a doctor before taking new supplements is advised.

It is essential to consult a healthcare provider before starting any new supplement, especially if you have underlying health conditions or are taking medications.

Source: “Dietary Supplements: Regulatory Challenges and Research Resources” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793269/

Claim: Animal studies have shown promising results regarding heart health, diabetes, and cancer prevention.
Fact check: True. Animal studies have shown promise for resveratrol in these areas.

Animal studies have shown that resveratrol may have beneficial effects on heart health, diabetes, and cancer prevention.

Source: “Resveratrol-Potential Antibacterial Agent against Foodborne Pathogens” https://pubmed.ncbi.nlm.nih.gov/29515440/

Claim: However, human studies have shown mixed results. Some studies have demonstrated benefits, while others have not found significant effects.
Fact check: True. Human studies on resveratrol have had varying results.

Studies involving humans have shown varying results regarding the benefits of resveratrol; some studies show promising benefits, while other studies show no significant impact, indicating that more research is needed.

Source: “Resveratrol and health–a comprehensive review of human clinical trials” https://pubmed.ncbi.nlm.nih.gov/21688389/

Claim: Current research is focused on identifying effective doses for humans.
Fact check: True. Dose optimization is a current focus of resveratrol research.

Current resveratrol research is focused on identifying appropriate doses for humans and also understanding how resveratrol interacts with other compounds in the body.

Source: “Resveratrol in metabolic health: an overview of the current evidence and perspectives.” https://pubmed.ncbi.nlm.nih.gov/23855468/

Claim: Grapes are an excellent way to consume resveratrol. Try including them in your breakfast or as a snack.
Fact check: True. Grapes are a good dietary source of resveratrol.

Grapes, especially red and purple varieties, are excellent sources of resveratrol. Including them in your meals and snacks can be beneficial.

Source: “Resveratrol: A Fair Race Towards Replacing Sulfites in Wines” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288175/

Claim: Berries such as blueberries and cranberries also contain resveratrol and make great additions to yogurt or oatmeal.
Fact check: True. Blueberries and cranberries also contain resveratrol.

Berries, particularly blueberries and cranberries, contain resveratrol and can make a healthy addition to your diet.

Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/

Claim: While red wine contains resveratrol, drinking too much alcohol can be harmful to your health.
Fact check: True. Excessive alcohol consumption is harmful.

While red wine is a source of resveratrol, excessive alcohol consumption can have negative effects on health, therefore moderation is important.

Source: “An orbitocortical-thalamic circuit suppresses binge alcohol-drinking” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11245026/

Claim: Foods contain a variety of beneficial compounds that work together.
Fact check: True. Whole foods have synergistic benefits due to multiple compounds.

Whole foods contain a variety of compounds that often work synergistically to provide benefits, and may be more effective than single isolated compounds.

Source: “Designing Nutrition for Health—Incorporating Dietary By-Products into Poultry Feeds to Create Functional Foods with Insights into Health Benefits, Risks, Bioactive Compounds, Food Component Functionality and Safety Regulations” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650119/

Claim: Red grapes, blueberries, cranberries, and peanuts are rich sources of resveratrol.
Fact check: True. These are all rich sources of resveratrol.

Red grapes, blueberries, cranberries, and peanuts are indeed rich sources of resveratrol. Red wine also contains resveratrol, but in relatively small amounts compared to the raw ingredients.

Source: “Resveratrol Food Supplement Products and the Challenges of Accurate Label Information to Ensure Food Safety for Consumers” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861762/

Claim: Studies have used doses ranging from 150 mg to 1000 mg per day.
Fact check: True. This is a common dose range used in studies.

Studies have used a wide range of doses, from 150mg up to 1000mg per day when conducting research on resveratrol.

Source: “Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10815776/

Claim: Some animal studies suggest resveratrol might help with weight management.
Fact check: Potentially True, based on some animal research.

Some animal studies have shown that resveratrol may have some effect on weight management, but more research is needed, especially in human subjects.

Source: “A Comprehensive Analysis of the Efficacy of Resveratrol in Atherosclerotic Cardiovascular Disease, Myocardial Infarction and Heart Failure” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587649/

Claim: The safety of resveratrol supplements during pregnancy isn’t well established.
Fact check: True. Resveratrol supplement safety during pregnancy is not well-established.

The safety of resveratrol supplements during pregnancy has not been well established, therefore it is best to err on the side of caution.

Source: “Resveratrol ameliorates mitochondrial biogenesis and reproductive outcomes in women with polycystic ovary syndrome undergoing assisted reproduction: a randomized, triple-blind, placebo-controlled clinical trial” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234766/

Claim: Yes, resveratrol can interact with certain medications, particularly those processed by the liver.
Fact check: True. Resveratrol can interact with liver-processed medications.

Resveratrol can potentially interact with certain medications, especially those that are processed through the liver, affecting drug metabolism and increasing the risk of side effects.

Source: “Transporter-mediated natural product–drug interactions for the treatment of cardiovascular diseases” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326887/

Claim: Some studies have shown effects after a few weeks, while others looked at longer periods.
Fact check: True. The timeline for effects varies in studies.

Different studies have shown variable results, with some suggesting effects after a few weeks of supplementation, while others looked at longer periods.

Source: “Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10815776/

Claim: While resveratrol has shown anti-aging effects in some animal studies, there’s no evidence it can reverse aging in humans.
Fact check: True. No evidence that Resveratrol can reverse human aging.

Resveratrol has shown potential anti-aging effects in some animal studies. However, there’s currently no evidence to suggest that resveratrol can reverse the aging process in humans. While it may support healthy aging as part of a balanced diet and lifestyle, it does not have rejuvenating properties.

Source: “Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348580/


Medically reviewed and fact checked

Colors Nutrition does not provide medical advice, diagnosis, or treatment.