Takeaways
- Resveratrol is a natural compound found in grapes, berries, and peanuts
- It has potential benefits for heart health and longevity
- Resveratrol acts as an antioxidant and anti-inflammatory agent
- Red wine contains resveratrol but in small amounts
- Supplements can provide higher doses, but more research is needed
- A balanced diet rich in plant foods is the best way to get resveratrol
What is Resveratrol?
Resveratrol is a naturally occurring substance found in some plants. It’s classified as a polyphenol, a type of compound known for its antioxidant properties.[1] Plants produce resveratrol as a defense mechanism against injury and disease.[2]
Resveratrol was first identified by scientists in 1939, but it didn’t attract significant interest until the 1990s.[3] This shift in attention occurred when researchers began exploring its potential link to the health advantages associated with red wine.[4]
Resveratrol is categorized as a stilbenoid, which is a specific type of plant compound.[5] Its unique chemical structure allows it to interact with different molecules inside the body.[6] This interaction is thought to be the basis for resveratrol’s potential positive effects on health.
Natural Sources of Resveratrol
Plant-Based Sources
Resveratrol is produced by various plants under certain conditions. It often appears in response to stress, such as injury or exposure to pathogens. Common plant sources include the skin of grapes, blueberries, and peanuts.[7]
The quantity of resveratrol found in plants can differ. Factors like the climate, how the plants are grown, and the specific type of plant influence these levels.[8] For example, grapes grown in cooler temperatures often have a higher resveratrol content.[9]
Here are some common food sources that contain resveratrol:
- Red grapes
- Blueberries
- Cranberries
- Peanuts
- Pistachios
- Dark chocolate
Red Wine and Grapes
Red wine and grapes are among the most well-known sources of resveratrol. The compound is concentrated in the grape skins. Red wine has higher levels than white wine because it’s fermented with the grape skins still included.[10]
The amount of resveratrol varies across different kinds of grapes. Environmental factors also play a significant role. Grapes that have been exposed to fungal pressure tend to generate more resveratrol as part of their defense response.[11]
Here’s a table outlining the resveratrol content in various wine and grape products:
| Product | Resveratrol Content (mg/L) |
|---|---|
| Red wine | 0.1 – 14.3 |
| White wine | 0.1 – 2.1 |
| Red grape juice | 1.14 – 8.69 |
| White grape juice | 0.05 – 1.08 |
Health Benefits of Resveratrol
Cardiovascular Health
Resveratrol may provide benefits to the heart in several ways. Research suggests it might help improve cholesterol and blood pressure levels.[12]
Studies indicate that resveratrol could reduce inflammation within blood vessels.[13] This reduction may contribute to preventing plaque buildup, a cause of heart disease. Some studies also suggest that resveratrol might improve how well blood vessels function.
It’s important to know that most studies on resveratrol have been conducted using animals or in laboratory settings.[14] More research involving human subjects is necessary to verify these results. Also, the doses of resveratrol used in studies are often higher than those obtained through diet.[15]
Anti-Inflammatory Effects
Numerous studies have indicated that resveratrol possesses anti-inflammatory properties.[16] Inflammation is a factor in many chronic illnesses. Therefore, by reducing inflammation, resveratrol may help prevent or manage these conditions.
Research suggests resveratrol can hinder inflammatory molecules in the body.[17] It might also activate certain genes that help fight inflammation.[18] These effects have been observed in both animal and human research.
Here are some health conditions that may benefit from resveratrol’s anti-inflammatory effects:
- Arthritis
- Heart disease
- Diabetes
- Alzheimer’s disease
- Some types of cancer
Antioxidant Properties
Resveratrol is a notable antioxidant. Antioxidants protect cells from damage caused by free radicals.[19] Free radicals are unstable molecules that can harm DNA and other cell structures.
By neutralizing free radicals, resveratrol may help prevent cellular damage. This could potentially slow down the aging process and reduce the likelihood of certain diseases. Some studies suggest resveratrol may be more effective than vitamins C and E in specific antioxidant functions.[20]
The antioxidant characteristics of resveratrol could offer protection against:
- Heart disease
- Cancer
- Alzheimer’s disease
- Parkinson’s disease
- Age-related macular degeneration
Potential Cancer-Fighting Properties
Resveratrol has shown promise in studies related to cancer. Lab and animal experiments suggest that it could help prevent cancer cells from growing and spreading.[21]
Various ways resveratrol could potentially fight cancer have been suggested. It might disrupt the growth and division of cancer cells.[22] Resveratrol may also trigger the death of these cells.[23] Some studies indicate it could make cancer cells more responsive to chemotherapy.[24]
It’s important to understand the limits of current research. Most of the studies have been done in laboratories or with animals. Human studies are limited, and they have produced varying results. More research is needed to know if resveratrol can effectively help prevent or treat cancer in humans.
Resveratrol and Longevity
The “French Paradox”
The term “French Paradox” describes the observation that people in France have low rates of heart disease.[25] This is despite a diet that is high in saturated fats. Some researchers have proposed that red wine consumption might be part of the explanation.[26]
This theory brought more interest to resveratrol, a substance found in red wine. Scientists wanted to know if resveratrol could be responsible for the potential heart-protective effects of red wine.
However, further research has revealed a more complex picture. The French diet also includes many other healthy foods. These include fresh fruits, vegetables, and whole grains. Lifestyle habits, such as physical activity, also contribute. While resveratrol might have some health benefits, it’s likely not the sole reason for the French Paradox.[27]
Calorie Restriction Mimetic
Resveratrol is being studied as a potential calorie restriction mimetic. Calorie restriction is known to extend life in several species.[28] A calorie restriction mimetic is a substance that produces similar effects to calorie restriction, without actually reducing food intake.
Studies suggest that resveratrol might activate certain proteins called sirtuins.[29] Sirtuins play a role in aging and how the body uses energy. By activating these proteins, resveratrol might generate some of the same benefits as calorie restriction.[30]
Animal studies have shown positive results. Resveratrol increased the lifespan of yeast, worms, and fish.[31] It also improved the health of mice that were fed a high-calorie diet. However, there aren’t many human studies in this area. More research is required to determine if resveratrol can mimic calorie restriction in humans.
Absorption and Bioavailability
The way resveratrol is absorbed by the human body is intricate. When ingested, it is quickly absorbed in the intestines. However, the liver also rapidly breaks it down.[32] This results in very little resveratrol actually reaching the bloodstream.[33]
Several factors influence how much resveratrol the body can use. These include the type of food it’s in, how it’s taken, and individual differences in how the body processes it. For instance, consuming resveratrol with a meal that contains fat might improve how well it’s absorbed.[34]
Here is a table that compares how well resveratrol is absorbed from various sources:
| Source | Bioavailability |
|---|---|
| Red wine | Low |
| Grape juice | Low |
| Whole grapes | Medium |
| Supplements | Variable |
Researchers are currently looking for ways to make it easier for the body to absorb resveratrol. Some of these strategies include:
- Using more bioavailable forms of resveratrol
- Combining resveratrol with other compounds that enhance absorption
- Developing novel delivery systems, such as nanoparticles
Resveratrol Supplements
Types of Supplements
Resveratrol supplements are available in several forms. These include capsules, tablets, powders, and liquid extracts. Some supplements contain pure resveratrol, while others have a mix of compounds.
Here is a list of common types of resveratrol supplements:
- Trans-resveratrol (the most active form)
- Resveratrol from Japanese knotweed extract
- Grape seed extract with resveratrol
- Red wine extract
- Mixed polyphenol supplements containing resveratrol
When choosing a supplement, it’s important to consider factors such as purity, dosage, and whether it has been tested by a third party.[35] Look for products that specify the amount of trans-resveratrol they contain.[36] This is the form that has been most studied for its health effects.
Dosage and Safety
The dosage of resveratrol in supplements can vary quite a bit. Most studies have used doses ranging from 150 mg to 1000 mg per day.[37] However, the ideal dose for humans is not yet known.
While resveratrol is generally considered safe, it may cause some side effects in certain individuals. These can include:
- Nausea
- Stomach upset
- Headache
- Fatigue
Resveratrol could interact with some medications. It may affect how the liver breaks down drugs.[38] This could potentially increase the risk of side effects from those medications.
Always consult a doctor before starting any new supplement.[39] This is particularly important if you have pre-existing health conditions or are taking medications. They can help determine if resveratrol supplements are appropriate for you and what dosage to use.
Research and Clinical Studies
Resveratrol has been extensively studied. Much of the early research involved laboratory experiments and animal studies. In recent years, more studies involving humans have been conducted.
Animal studies have shown promising results regarding heart health, diabetes, and cancer prevention.[40] However, human studies have shown mixed results. Some studies have demonstrated benefits, while others have not found significant effects.[41]
Here’s a timeline highlighting significant milestones in resveratrol research:
- 1939: Resveratrol first isolated from white hellebore
- 1992: Resveratrol identified in red wine
- 1997: First study suggesting anti-cancer effects
- 2003: Study showing resveratrol extends lifespan in yeast
- 2006: Resveratrol improves health of mice on high-calorie diet
- 2010: First long-term study of resveratrol in humans published
- 2015: Meta-analysis shows resveratrol may improve some cardiovascular risk factors
Current research is focused on identifying effective doses for humans.[42] Scientists are also studying how resveratrol interacts with other compounds in the body. Further long-term human studies are necessary to fully understand resveratrol’s effects.
Incorporating Resveratrol in Your Diet
Adding resveratrol to your diet doesn’t require significant changes. This compound is found in many healthy and delicious foods. The key is to eat a balanced diet that includes a variety of plant-based options.
Grapes are an excellent way to consume resveratrol. Try including them in your breakfast or as a snack.[43] Berries such as blueberries and cranberries also contain resveratrol and make great additions to yogurt or oatmeal.[44]
Here is a list of recipe ideas that are rich in resveratrol:
- Berry smoothie with mixed berries and grape juice
- Spinach salad with red grapes and chopped peanuts
- Dark chocolate-covered berries for dessert
- Homemade trail mix with peanuts and dried cranberries
Remember that moderation is important. While red wine contains resveratrol, drinking too much alcohol can be harmful to your health.[45] If you choose to drink, follow the recommended guidelines.
While supplements are an option, it is generally better to get nutrients from whole foods whenever possible. Foods contain a variety of beneficial compounds that work together.[46] This combination of compounds may offer more advantages than isolated supplements.
FAQ: People Also Ask
In summary, resveratrol is an interesting compound with potential health benefits. While research is still ongoing, incorporating foods rich in resveratrol into a balanced diet is a safe and possibly beneficial step. It’s also important to remember that no single compound is a solution for health. A varied diet, regular physical activity, and a generally healthy lifestyle are the foundations of good health.What foods contain the most resveratrol?
How much resveratrol should I take daily?
Can resveratrol help with weight loss?
Is resveratrol safe during pregnancy?
Does resveratrol interact with medications?
How long does it take to see benefits from resveratrol?
Is resveratrol better from food or supplements?
Can resveratrol reverse aging?
Resveratrol is indeed a naturally occurring polyphenol found in various plants. Polyphenols are known for their antioxidant effects, which can help protect cells from damage.
Source: “Resveratrol: A Double-Edged Sword in Health Benefits” https://pubmed.ncbi.nlm.nih.gov/30205595/
Plants synthesize resveratrol in response to various stressors, such as fungal infections, injury, and UV radiation. This production is part of the plant’s defense system.
Source: “Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101422/
Resveratrol was first isolated in 1939, but it did not become the focus of intensive research until the 1990s, when its potential health benefits started being explored.
The link between red wine consumption and potential health benefits led to increased research focus on resveratrol, as it is one of the main polyphenols found in red wine.
Source: “The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610408/
Stilbenoids are a specific class of plant compounds, and resveratrol falls within this group, characterized by their chemical structure.
Source: “Characterization of Some Stilbenoids Extracted from Two Cultivars of Lambrusco—Vitis vinifera Species: An Opportunity to Valorize Pruning Canes for a More Sustainable Viticulture” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222724/
Resveratrol’s specific chemical structure enables it to bind to and interact with various molecules within the body, which is thought to be the basis for its potential health benefits.
Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/
Grapes, especially the skin, blueberries, and peanuts are among the commonly cited food sources of resveratrol. However, the amount can vary depending on various factors.
Source: “Resveratrol Food Supplement Products and the Challenges of Accurate Label Information to Ensure Food Safety for Consumers” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861762/
The concentration of resveratrol in plants is affected by environmental conditions like climate, growing practices, and the specific variety of the plant, demonstrating the complexities of its presence in natural sources.
Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/
Research has indicated that grapes cultivated in cooler climates tend to produce higher levels of resveratrol as a stress response.
Source: “Effects of Traditional and Modern Post-Harvest Withering Processes on the Composition of the Vitis v. Corvina Grape and the Sensory Profile of Amarone Wines” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434166/
The winemaking process of red wine includes fermentation with the grape skins, allowing for more resveratrol to be extracted into the final product. In white winemaking, the skins are generally removed before fermentation.
Source: “Resveratrol and endothelial function: A literature review.” https://pubmed.ncbi.nlm.nih.gov/34119624/
Exposure to fungal pathogens triggers a defensive mechanism in grapes, leading to increased production of resveratrol as a protective compound.
Source: “An Overview of Stress-Induced Resveratrol Synthesis in Grapes: Perspectives for Resveratrol-Enriched Grape Products” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155908/
Some studies suggest that resveratrol may have a positive impact on cholesterol levels and blood pressure, but more human research is needed to confirm these effects.
Source: “The Role of Diet in the Prevention of Hypertension and Management of Blood Pressure: An Umbrella Review of Meta-Analyses of Interventional and Observational Studies” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10831905/
Studies suggest that resveratrol may have anti-inflammatory effects in blood vessels, which could potentially help prevent cardiovascular diseases. However, these findings need confirmation in human trials.
Source: “Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516162/
Most of the existing research on resveratrol has been conducted in laboratory settings or using animal models, so further human research is essential to validate these results in people.
Source: “Research progress of SIRTs activator resveratrol and its derivatives in autoimmune diseases” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219927/
Studies often utilize doses of resveratrol that are significantly higher than the typical levels obtained through food intake, highlighting a potential limitation for extrapolating results to dietary consumption.
Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/
Research has consistently shown that resveratrol can exhibit anti-inflammatory activity in both laboratory and animal studies, although human studies are still needed to confirm.
Source: “Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516162/
Resveratrol has been observed to affect various inflammatory pathways, potentially hindering inflammatory molecules and signaling, which suggests a possible mechanism for its anti-inflammatory effects.
Source: “Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770891/
Resveratrol may impact the expression of genes involved in the inflammatory response. However, further research is required to fully determine the extent and significance of these interactions.
As an antioxidant, resveratrol can protect cells from damage caused by unstable molecules called free radicals.
Source: “Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348580/
Resveratrol may exhibit higher potency in specific antioxidant functions compared to vitamins C and E in some in vitro and animal studies, but more research is needed to confirm this in humans.
Source: “Can Compounds of Natural Origin Be Important in Chemoprevention? Anticancer Properties of Quercetin, Resveratrol, and Curcumin—A Comprehensive Review” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11050349/
Laboratory and animal studies suggest that resveratrol could potentially inhibit cancer cell growth and metastasis, but more human clinical trials are needed to confirm this.
Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/
Studies have shown that Resveratrol has shown to have anti-proliferative properties on different cancer cell lines, which could play a role in preventing cancer growth and progression.
Source: “Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471701/
Resveratrol has been shown to induce apoptosis (programmed cell death) in various cancer cell lines in vitro, suggesting a potential role in cancer treatment.
Source: “Mechanism of Resveratrol-Induced Programmed Cell Death and New Drug Discovery against Cancer: A Review” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697740/
Some studies suggest that resveratrol could potentially enhance the sensitivity of cancer cells to chemotherapy, thereby improving treatment outcomes, but more human research is needed to confirm.
Source: “Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101422/
The term ‘French Paradox’ refers to the seemingly contradictory observation that the French population tends to have lower rates of heart disease despite consuming a diet high in saturated fats.
Source: “Between the Devil and the Deep Blue Sea—Resveratrol, Sulfotransferases and Sulfatases—A Long and Turbulent Journey from Intestinal Absorption to Target Cells” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140952/
Some researchers have theorized that red wine consumption, with its compounds like resveratrol, might play a role in the French Paradox by providing cardiovascular benefits.
Source: “Health Effects of Red Wine Consumption: A Narrative Review of an Issue That Still Deserves Debate” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146095/
While resveratrol might contribute to some health benefits, it is now recognized that the French Paradox is likely influenced by a combination of dietary and lifestyle factors, not just red wine or resveratrol.
Source: “The social marketing paradox: challenges and opportunities for the discipline” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380297/
Studies across various organisms, including yeast, worms, flies, and rodents, have consistently shown that calorie restriction (reducing calorie intake without malnutrition) can extend lifespan and improve health.
Source: “The Absence of Attentional Bias to Low-Calorie Food Stimuli in Restrictive Dieters: Differences in the Allocation of Attentional Resources to High-Calorie Foods” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11201999/
Research has shown that resveratrol may activate sirtuins, which are proteins involved in cellular health, aging, and metabolism.
Resveratrol’s proposed mechanism of action includes activating sirtuins. Therefore, it is theorized that it could be a possible ‘calorie restriction mimetic’ and could potentially replicate the benefits of calorie restriction.
Source: “Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348580/
Resveratrol has been shown to increase lifespan in animal model studies, such as yeast, worms and fish.
Source: “Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span” https://pubmed.ncbi.nlm.nih.gov/32758058/
When ingested, Resveratrol is rapidly absorbed in the intestines but is also rapidly metabolized by the liver, which reduces its bioavailability in the body.
Source: “Resveratrol‐loaded nanomedicines for cancer applications” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222557/
Due to its rapid metabolism, only a small amount of the ingested resveratrol reaches the bloodstream, highlighting a major challenge in its bioavailability.
Source: “Enzymatic Synthesis of Resveratrol α-Glucoside by Amylosucrase of Deinococcus geothermalis” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706033/
Studies have shown that consuming resveratrol with a meal that contains fat can enhance its absorption and bioavailability in the body, due to its lipophilic nature.
Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/
When selecting resveratrol supplements, it is important to consider factors such as purity, dosage, and if the supplement has undergone third-party testing to ensure quality and safety.
Source: “Dietary Supplements: Regulatory Challenges and Research Resources” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793269/
It is advisable to choose supplements that specifically state the amount of trans-resveratrol because this is the form most studied for potential health benefits.
Source: “Pharmacological effects of polydatin in the treatment of metabolic diseases: A review” https://pubmed.ncbi.nlm.nih.gov/35636169/
Clinical studies often use resveratrol dosages ranging from 150 mg to 1000 mg per day; however, optimal dosages for specific health benefits are still not clearly defined.
Source: “Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10815776/
Resveratrol can potentially interact with certain medications by affecting how the liver metabolizes them, thereby altering the effects and increasing the risk of side effects.
Source: “Transporter-mediated natural product–drug interactions for the treatment of cardiovascular diseases” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326887/
It is essential to consult a healthcare provider before starting any new supplement, especially if you have underlying health conditions or are taking medications.
Source: “Dietary Supplements: Regulatory Challenges and Research Resources” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793269/
Animal studies have shown that resveratrol may have beneficial effects on heart health, diabetes, and cancer prevention.
Source: “Resveratrol-Potential Antibacterial Agent against Foodborne Pathogens” https://pubmed.ncbi.nlm.nih.gov/29515440/
Studies involving humans have shown varying results regarding the benefits of resveratrol; some studies show promising benefits, while other studies show no significant impact, indicating that more research is needed.
Source: “Resveratrol and health–a comprehensive review of human clinical trials” https://pubmed.ncbi.nlm.nih.gov/21688389/
Current resveratrol research is focused on identifying appropriate doses for humans and also understanding how resveratrol interacts with other compounds in the body.
Source: “Resveratrol in metabolic health: an overview of the current evidence and perspectives.” https://pubmed.ncbi.nlm.nih.gov/23855468/
Grapes, especially red and purple varieties, are excellent sources of resveratrol. Including them in your meals and snacks can be beneficial.
Source: “Resveratrol: A Fair Race Towards Replacing Sulfites in Wines” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288175/
Berries, particularly blueberries and cranberries, contain resveratrol and can make a healthy addition to your diet.
Source: “Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151233/
While red wine is a source of resveratrol, excessive alcohol consumption can have negative effects on health, therefore moderation is important.
Source: “An orbitocortical-thalamic circuit suppresses binge alcohol-drinking” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11245026/
Whole foods contain a variety of compounds that often work synergistically to provide benefits, and may be more effective than single isolated compounds.
Source: “Designing Nutrition for Health—Incorporating Dietary By-Products into Poultry Feeds to Create Functional Foods with Insights into Health Benefits, Risks, Bioactive Compounds, Food Component Functionality and Safety Regulations” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650119/
Red grapes, blueberries, cranberries, and peanuts are indeed rich sources of resveratrol. Red wine also contains resveratrol, but in relatively small amounts compared to the raw ingredients.
Source: “Resveratrol Food Supplement Products and the Challenges of Accurate Label Information to Ensure Food Safety for Consumers” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861762/
Studies have used a wide range of doses, from 150mg up to 1000mg per day when conducting research on resveratrol.
Source: “Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10815776/
Some animal studies have shown that resveratrol may have some effect on weight management, but more research is needed, especially in human subjects.
Source: “A Comprehensive Analysis of the Efficacy of Resveratrol in Atherosclerotic Cardiovascular Disease, Myocardial Infarction and Heart Failure” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587649/
The safety of resveratrol supplements during pregnancy has not been well established, therefore it is best to err on the side of caution.
Source: “Resveratrol ameliorates mitochondrial biogenesis and reproductive outcomes in women with polycystic ovary syndrome undergoing assisted reproduction: a randomized, triple-blind, placebo-controlled clinical trial” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234766/
Resveratrol can potentially interact with certain medications, especially those that are processed through the liver, affecting drug metabolism and increasing the risk of side effects.
Source: “Transporter-mediated natural product–drug interactions for the treatment of cardiovascular diseases” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326887/
Different studies have shown variable results, with some suggesting effects after a few weeks of supplementation, while others looked at longer periods.
Source: “Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10815776/
Resveratrol has shown potential anti-aging effects in some animal studies. However, there’s currently no evidence to suggest that resveratrol can reverse the aging process in humans. While it may support healthy aging as part of a balanced diet and lifestyle, it does not have rejuvenating properties.
Source: “Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348580/
